发明授权
- 专利标题: TRIARYLCARBOXYLIC ACID DERIVATIVE
- 专利标题(中): 三芳基羧酸衍生物
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申请号: EP06811388.5申请日: 2006-10-06
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公开(公告)号: EP1932832B1公开(公告)日: 2010-12-01
- 发明人: SATO, Junji , HATTORI, Kazuyuki , KUBOTA, Hirokazu , MUNAKATA, Ryosuke , ASANO, Toru , MAEDA (WATANABE), Junko. , KAWAKAMI, Masakatsu , KAMIKAWA, Akio
- 申请人: Astellas Pharma Inc.
- 申请人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 代理机构: HOFFMANN EITLE
- 优先权: JP2005295740 20051007
- 国际公布: WO2007043457 20070419
- 主分类号: C07D213/79
- IPC分类号: C07D213/79 ; A61K31/381 ; A61K31/4025 ; A61K31/404 ; A61K31/415 ; A61K31/4155 ; A61K31/42 ; A61K31/425 ; A61K31/426 ; A61K31/427 ; A61K31/4418 ; A61P19/06
摘要:
It is intended to provide a remedy or a preventive for hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinitis and so on which has a non-nucleic acid structure and exerts an excellent xanthine oxidase inhibitory effect and a uric acid level-lowering effect. It has been confirmed that a novel triarylcarboxlic acid derivative, which is characterized by having a carboxyl-substituted heteroaryl group and an aromatic ring group such as a phenyl group attached in para-position on a benzene ring and further carrying a cyano group on the same benzene ring, has a potent xanthine oxidase inhibitory effect and a uric acid level-lowering effect. Thus, it is found out that this compound is appropriately usable as a remedy or a preventive for hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinitis and so on.
公开/授权文献
- EP1932832A1 TRIARYLCARBOXYLIC ACID DERIVATIVE 公开/授权日:2008-06-18
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