发明公开
EP1964838A1 Process for the resolution of homocysteine-thiolactone
有权
Verfahren zurAuflösungvon Homocystein-Thiolacton
- 专利标题： Process for the resolution of homocysteine-thiolactone
- 专利标题（中）： Verfahren zurAuflösungvon Homocystein-Thiolacton
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申请号： EP07004341.9申请日： 2007-03-02
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公开(公告)号： EP1964838A1公开(公告)日： 2008-09-03
- 发明人: Nicola, Massimo , Gatti, Pier Andrea , Zacche, Matteo
- 申请人： EDMOND PHARMA S.R.L.
- 申请人地址： Via G. B. Grassi 15 20157 Milano IT
- 专利权人： EDMOND PHARMA S.R.L.
- 当前专利权人： EDMOND PHARMA S.R.L.
- 当前专利权人地址： Via G. B. Grassi 15 20157 Milano IT
- 代理机构： Minoja, Fabrizio
- 主分类号： C07D333/36
- IPC分类号： C07D333/36
摘要：
The present invention relates to a process for the preparation of enantiomerically pure homocysteine-γ-thiolactone comprising optical resolution of racemic homocysteine-γ-thiolactone ( I )
with a chiral organic acid wherein one isomer is recovered as diastereomeric salt with the organic acid and the other isomer remaining in the mother liquor is submitted to racemisation with a catalytic amount of an aromatic aldehyde and submitted again to optical resolution with the same chiral organic acid.
with a chiral organic acid wherein one isomer is recovered as diastereomeric salt with the organic acid and the other isomer remaining in the mother liquor is submitted to racemisation with a catalytic amount of an aromatic aldehyde and submitted again to optical resolution with the same chiral organic acid.
公开/授权文献
- EP1964838B1 Process for the resolution of homocysteine-thiolactone 公开/授权日：2009-12-30
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