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    Process for the resolution of homocysteine-thiolactone
    5.
    发明公开
    Process for the resolution of homocysteine-thiolactone 有权
    Verfahren zurAuflösungvon Homocystein-Thiolacton

    公开(公告)号：EP1964838A1

    公开(公告)日：2008-09-03

    申请号：EP07004341.9

    申请日：2007-03-02

    申请人： EDMOND PHARMA S.R.L.

    发明人： Nicola, Massimo ,  Gatti, Pier Andrea ,  Zacche, Matteo

    IPC分类号： C07D333/36

    CPC分类号： C07D333/36

    摘要： The present invention relates to a process for the preparation of enantiomerically pure homocysteine-γ-thiolactone comprising optical resolution of racemic homocysteine-γ-thiolactone ( I )

    with a chiral organic acid wherein one isomer is recovered as diastereomeric salt with the organic acid and the other isomer remaining in the mother liquor is submitted to racemisation with a catalytic amount of an aromatic aldehyde and submitted again to optical resolution with the same chiral organic acid.

    摘要翻译： 本发明涉及一种制备对映体纯的同型半胱氨酸-3-硫内酯的方法，其包括用手性有机酸旋光拆分外消旋高半胱氨酸-3-硫内酯（I），其中一种异构体作为与有机酸的非对映体盐一起回收， 保留在母液中的其它异构体用催化量的芳族醛进行外消旋化，并再次用相同的手性有机酸进行光学拆分。

    The use of homocysteine derivatives for the preparation of medicaments inhibiting bacterial adhesiveness
    6.
    发明公开
    The use of homocysteine derivatives for the preparation of medicaments inhibiting bacterial adhesiveness 有权
    使用同型半胱氨酸衍生物用于制备药物的用于预防Bakterienadhesion的

    公开(公告)号：EP0974353A3

    公开(公告)日：2000-03-08

    申请号：EP99110376.3

    申请日：1999-05-28

    申请人： EDMOND PHARMA S.R.L.

    发明人： Nicola, Massimo ,  Inglesi, Marco

    IPC分类号： A61K31/195 ,  A61K31/38

    CPC分类号： A61K31/198 ,  A61K31/381

    摘要： The use of N-(thiodiglycoyl)homocysteine, of the pharmaceutically acceptable salts thereof and of the metabolic precursors thereof for the preparation of medicaments for inhibiting bacterial adhesiveness. Novel metabolic precursors of N-(thiodiglycoyl)homocysteine are also disclosed.

    摘要翻译： 体和其代谢前体药物用于抑制细菌粘附性的制剂的可接受的盐的用途，药学的N-（thiodiglycoyl）同型半胱氨酸，。 N-（thiodiglycoyl）同型半胱氨酸的新颖代谢前体因此被游离缺失光盘。

    The use of homocysteine derivatives for the preparation of medicaments inhibiting bacterial adhesiveness
    7.
    发明公开
    The use of homocysteine derivatives for the preparation of medicaments inhibiting bacterial adhesiveness 有权
    Verwendung von Homocysteinderivaten zur Behandlung von bakteriellen Infektionen

    公开(公告)号：EP0974353A2

    公开(公告)日：2000-01-26

    申请号：EP99110376.3

    申请日：1999-05-28

    申请人： EDMOND PHARMA S.R.L.

    发明人： Nicola, Massimo ,  Inglesi, Marco

    IPC分类号： A61K31/195 ,  A61K31/38

    CPC分类号： A61K31/198 ,  A61K31/381

    摘要： The use of N-(thiodiglycoyl)homocysteine, of the pharmaceutically acceptable salts thereof and of the metabolic precursors thereof for the preparation of medicaments for inhibiting bacterial adhesiveness. Novel metabolic precursors of N-(thiodiglycoyl)homocysteine are also disclosed.

    摘要翻译： N-（硫代二乙酰基）高半胱氨酸及其药学上可接受的盐及其代谢前体在制备用于抑制细菌粘附性的药物中的用途。 还公开了N-（硫代二乙酰基）高半胱氨酸的新型代谢前体。