发明授权
- 专利标题: PYRROLE DERIVATIVE OR SALT THEREOF
- 专利标题(中): 吡咯或其盐
-
申请号: EP07714469.9申请日: 2007-02-19
-
公开(公告)号: EP1988075B1公开(公告)日: 2012-01-25
- 发明人: SEO, Ryushi , KAKU, Hidetaka , YAMADA, Hiroyoshi , KAGA, Daisuke , AKUZAWA, Shinobu
- 申请人: Astellas Pharma Inc.
- 申请人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 代理机构: HOFFMANN EITLE
- 优先权: JP2006041830 20060220
- 国际公布: WO2007097276 20070830
- 主分类号: C07D207/34
- IPC分类号: C07D207/34 ; A61K31/40 ; A61K31/4025 ; A61K31/404 ; A61K31/422 ; A61K31/433 ; A61K31/439 ; A61K31/454 ; A61K31/4725 ; A61P1/00 ; A61P43/00 ; C07D401/04 ; C07D401/10 ; C07D403/04 ; C07D407/04 ; C07D409/04 ; C07D409/12 ; C07D413/04 ; C07D417/04 ; C07D453/02
摘要:
[PROBLEMS] To provide a compound which can be used for the prevention and/or treatment of a disease associated with a 5-HT2B receptor or a 5-HT7 receptor, particularly for the treatment of irritable bowel syndrome (IBS). [MEANS FOR SOLVING PROBLEMS] It is found that a pyrrole derivative having a guanidinocarbonyl group or an amide group at position-3 as a substituent or a pharmaceutically acceptable salt thereof has a potent antagonistic effect on both of a 5-HT2B receptor and a 5-HT7 receptor. The compound shows a better pharmacological activity compared to an antagonist which is selective to either of these receptors. Therefore, the compound is useful for the prevention and/or treatment of a disease associated with a 5-HT2B receptor or a 5-HT7 receptor, particularly for the treatment of irritable bowel syndrome (IBS).
公开/授权文献
- EP1988075A1 PYRROLE DERIVATIVE OR SALT THEREOF 公开/授权日:2008-11-05
信息查询