发明公开
- 专利标题: AZOLECARBOXAMIDE DERIVATIVE
- 专利标题(中): AZOLECARBOXAMIDE衍生物
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申请号: EP07742444.8申请日: 2007-04-19
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公开(公告)号: EP2009005A1公开(公告)日: 2008-12-31
- 发明人: SUGASAWA, Keizo , KAWAGUCHI, Kenichi , MATSUZAWA, Takaho , SEO, Ryushi , HARADA, Hironori , SUGA, Akira , ABE, Tomoaki , AZAMI, Hidenori , MATSUMOTO, Shunichiro , SHIN, Takashi , TANAHASHI, Masayuki , WATANABE, Toru
- 申请人: Astellas Pharma Inc.
- 申请人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 代理机构: Gille Hrabal Struck Neidlein Prop Roos
- 优先权: JP2006115481 20060419
- 国际公布: WO2007123269 20071101
- 主分类号: C07D263/34
- IPC分类号: C07D263/34 ; A61K31/427 ; A61K31/438 ; A61K31/454 ; A61K31/4545 ; A61K31/496 ; A61K31/4985 ; A61K31/501 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; A61K31/55 ; A61K31/551 ; A61K31/553 ; A61P13/02 ; A61P13/08 ; A61P13/10 ; A61P19/02 ; A61P25/04 ; A61P43/00
摘要:
Provided is an agent for treating or preventing urinary frequency, urinary urgency and urinary, incontinence which are associated with overactive bladder, a lower urinary tract disease such as interstitial cystitis and chronic prostatitis accompanied by lower urinary tract pain, and various diseases accompanied by pain. A novel azolecarboxamide derivative in which an azole ring such as thioazole or oxazole is bonded to a benzene ring, pyridine ring or pyrimidine ring through carboxamide was confirmed to have a potent trkA receptor-inhibitory activity and found to be an agent for treating or preventing lower urinary tract disease and various diseases accompanied by pain, which is excellent in efficacy and safety, and thus the present invention was accomplished.
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