发明公开
- 专利标题： OXADIAZOLIDINEDIONE COMPOUND
- 专利标题（中）： 恶二唑啉二酮化合物
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申请号： EP07742129.5申请日： 2007-04-23
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公开(公告)号： EP2011788A1公开(公告)日： 2009-01-07
- 发明人: NEGORO, Kenji , IWASAKI, Fumiyoshi , OHNUKI, Kei , KUROSAKI, Toshio , YONETOKU, Yasuhiro , ASAI, Norio , YOSHIDA, Shigeru , SOGA, Takatoshi
- 申请人： Astellas Pharma Inc.
- 申请人地址： 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 代理机构： Gille Hrabal Struck Neidlein Prop Roos
- 优先权： JP2006118630 20060424
- 国际公布： WO2007123225 20071101
- 主分类号： C07D271/06
- IPC分类号： C07D271/06 ; A61K31/4245 ; A61K31/4439 ; A61P3/08 ; A61P3/10 ; A61P43/00 ; C07D413/12
摘要：
[Problem] A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided.
[Means for resolution] It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.
[Means for resolution] It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.
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