发明公开
- 专利标题： IMPURITIES OF DONEPEZIL
- 专利标题（中）： 污染多奈哌齐
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申请号： EP07732893.8申请日： 2007-05-18
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公开(公告)号： EP2027089A1公开(公告)日： 2009-02-25
- 发明人: KRIZMANIC, Irena , LERMAN, Lidija , SAMARDZIC, Zrinka, Mastelic , KACZOROWSKA, Katarzyna , MANIKOWSKI, Andrzej , ZIOBRO, Barbara , GREBENAR, Ivica , KORUZNJAK, Jasna, Dogan
- 申请人： PLIVA HRVATSKA d.o.o.
- 申请人地址： Ulica grada Vukovara 49 10000 Zagreb HR
- 专利权人： PLIVA HRVATSKA d.o.o.
- 当前专利权人： PLIVA HRVATSKA d.o.o.
- 当前专利权人地址： Ulica grada Vukovara 49 10000 Zagreb HR
- 代理机构： Bucks, Teresa Anne
- 优先权： GB0609835 20060518
- 国际公布： WO2007135408 20071129
- 主分类号： C07D211/32
- IPC分类号： C07D211/32 ; C07C225/18 ; G01N30/02 ; G01N30/90 ; G01N33/15 ; A61K31/445
摘要：
The present invention relates to impurities of donepezil, or a pharmaceutically acceptable salt thereof, which may be produced during synthesis and storage of donepezil, or a pharmaceutically-acceptable salt thereof, and to methods of identifying such impurities.The invention also relates to the use of these impurities in analytical techniques and to product that contain certain low levels of these impurities in particular the following impurities are disclosed: formula (I) and formula (II).
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