-
公开(公告)号：EP3784675A1
公开(公告)日：2021-03-03
申请号：EP19721957.9
申请日：2019-04-19
IPC分类号： C07D498/18 , A61P35/00 , A61K31/439
-
公开(公告)号：EP2043618A1
公开(公告)日：2009-04-08
申请号：EP07733428.2
申请日：2007-06-29
IPC分类号： A61K9/28 , A61K9/20 , A61K9/48 , A61K31/445
CPC分类号： A61K9/2018 , A61K9/2072 , A61K9/2866 , A61K9/4808 , A61K31/445
摘要： The present invention relates to a pharmaceutical composition comprising 2,3- dihydro-5,6-dimethoxy-2-[[1 -(phenylmethyl)-4-piperidinyl]methyl]-1 H-inden-1 -one, herein after referred to as Donepezil, or a pharmaceutically acceptable salt thereof, for treating of Alzheimer's disease and senile dementia. The present invention also relates to a manufacturing process for the preparation of Donepezil tablets containing and retaining polymorphic Form I of Donepezil hydrochloride. This composition also discloses the use of the excipients that ensure adequate flowability of a dry blend as well as required content uniformity and drug release rate of the final product.
-
公开(公告)号：EP3999514A1
公开(公告)日：2022-05-25
申请号：EP20750061.2
申请日：2020-07-10
IPC分类号： C07D498/18 , A61P35/00
-
公开(公告)号：EP2027089A1
公开(公告)日：2009-02-25
申请号：EP07732893.8
申请日：2007-05-18
发明人： KRIZMANIC, Irena , LERMAN, Lidija , SAMARDZIC, Zrinka, Mastelic , KACZOROWSKA, Katarzyna , MANIKOWSKI, Andrzej , ZIOBRO, Barbara , GREBENAR, Ivica , KORUZNJAK, Jasna, Dogan
IPC分类号： C07D211/32 , C07C225/18 , G01N30/02 , G01N30/90 , G01N33/15 , A61K31/445
CPC分类号： C07D211/32 , C07C225/18
摘要： The present invention relates to impurities of donepezil, or a pharmaceutically acceptable salt thereof, which may be produced during synthesis and storage of donepezil, or a pharmaceutically-acceptable salt thereof, and to methods of identifying such impurities.The invention also relates to the use of these impurities in analytical techniques and to product that contain certain low levels of these impurities in particular the following impurities are disclosed: formula (I) and formula (II).
-
-
-
搜索结果
4 条记录 (耗时 0.007 秒)
