公开(公告)号：EP2027089A1

公开(公告)日：2009-02-25

申请号：EP07732893.8

申请日：2007-05-18

申请人： PLIVA HRVATSKA d.o.o.

发明人： KRIZMANIC, Irena ,  LERMAN, Lidija ,  SAMARDZIC, Zrinka, Mastelic ,  KACZOROWSKA, Katarzyna ,  MANIKOWSKI, Andrzej ,  ZIOBRO, Barbara ,  GREBENAR, Ivica ,  KORUZNJAK, Jasna, Dogan

IPC分类号： C07D211/32 ,  C07C225/18 ,  G01N30/02 ,  G01N30/90 ,  G01N33/15 ,  A61K31/445

CPC分类号： C07D211/32 ,  C07C225/18

摘要： The present invention relates to impurities of donepezil, or a pharmaceutically acceptable salt thereof, which may be produced during synthesis and storage of donepezil, or a pharmaceutically-acceptable salt thereof, and to methods of identifying such impurities.The invention also relates to the use of these impurities in analytical techniques and to product that contain certain low levels of these impurities in particular the following impurities are disclosed: formula (I) and formula (II).

公开(公告)号：EP2046730A1

公开(公告)日：2009-04-15

申请号：EP07766184.1

申请日：2007-07-11

申请人： PLIVA HRVATSKA d.o.o.

发明人： MANIKOWSKI, Andrzej ,  KOLARSKA, Zofia ,  JERKOVIC, Juraj

IPC分类号： C07C253/30 ,  C07C253/34 ,  C07C255/41

CPC分类号： C07C253/30 ,  C07C253/34 ,  C07C255/41

摘要： The present invention relates to an improved process for isolation and purification of Entacapone, pharmaceutical compositions and therapeutic uses thereof. The process provides an improved yield and improved isomeric purity of produced Entacapone.