发明公开
- 专利标题： PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS
- 专利标题（中）： 吡啶和吡嗪，MNK激酶抑制剂
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申请号： EP07786791.9申请日： 2007-06-21
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公开(公告)号： EP2044051A1公开(公告)日： 2009-04-08
- 发明人: JENMALM JENSEN, Annika , RINGOM, Rune , MEDINA, Carmen , SHILVOCK, John , WIIK, Marie , KOOLMEISTER, Tobias , ANGBRANT, Johan , SUTIN, Lori , HENRIKSSON, Martin , SANDVALL, Teresa , JOHANSSON, Lars , NILSSON, Björn
- 申请人： BIOVITRUM AB (publ)
- 申请人地址： SE-112 76 Stockholm SE
- 专利权人： BIOVITRUM AB (publ)
- 当前专利权人： BIOVITRUM AB (publ)
- 当前专利权人地址： SE-112 76 Stockholm SE
- 优先权： SE0601379 20060622; US850067P 20061006
- 国际公布： WO2007147874 20071227
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D401/12 ; C07D403/12 ; C07D403/14 ; C07D405/12 ; C07D471/04
摘要：
The present invention relates to compounds of the general formula (I) wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.
公开/授权文献
- EP2044051B1 PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS 公开/授权日：2010-01-27
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