公开(公告)号：EP2044051B1

公开(公告)日：2010-01-27

申请号：EP07786791.9

申请日：2007-06-21

申请人： BIOVITRUM AB (publ)

发明人： JENMALM JENSEN, Annika ,  RINGOM, Rune ,  MEDINA, Carmen ,  SHILVOCK, John ,  WIIK, Marie ,  KOOLMEISTER, Tobias ,  ANGBRANT, Johan ,  SUTIN, Lori ,  HENRIKSSON, Martin ,  SANDVALL, Teresa ,  JOHANSSON, Lars ,  NILSSON, Björn

IPC分类号： C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04

CPC分类号： C07D401/12 ,  C07D401/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04

摘要： The present invention relates to compounds of the general formula (I) wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.

公开(公告)号：EP2044051A1

公开(公告)日：2009-04-08

申请号：EP07786791.9

申请日：2007-06-21

申请人： BIOVITRUM AB (publ)

发明人： JENMALM JENSEN, Annika ,  RINGOM, Rune ,  MEDINA, Carmen ,  SHILVOCK, John ,  WIIK, Marie ,  KOOLMEISTER, Tobias ,  ANGBRANT, Johan ,  SUTIN, Lori ,  HENRIKSSON, Martin ,  SANDVALL, Teresa ,  JOHANSSON, Lars ,  NILSSON, Björn

IPC分类号： C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04

CPC分类号： C07D401/12 ,  C07D401/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04

摘要： The present invention relates to compounds of the general formula (I) wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.