发明公开
EP2049486A2 PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
审中-公开
哌啶衍生物作为趋化因子受体活性的调节剂
- 专利标题： PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
- 专利标题（中）： 哌啶衍生物作为趋化因子受体活性的调节剂
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申请号： EP07763650.4申请日： 2007-01-25
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公开(公告)号： EP2049486A2公开(公告)日： 2009-04-22
- 发明人: CARTER, Percy, H. , CAVALLARO, Cullen, L. , DUNCIA, John, V. , GARDNER, Daniel, S. , HYNES, John , LIU, Rui-qin , SANTELLA, Joseph, B. , DODD, Dharmpal, S.
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： Route 206 and Province Line Road P.O. Box 4000 Princeton NJ 08543-4000 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： Route 206 and Province Line Road P.O. Box 4000 Princeton NJ 08543-4000 US
- 代理机构： Beacham, Annabel Rose
- 优先权： US762801P 20060127; US625874 20070123
- 国际公布： WO2007092681 20070816
- 主分类号： C07D211/18
- IPC分类号： C07D211/18 ; C07D211/38 ; C07D211/52 ; C07D211/58 ; C07D211/70 ; C07D401/12 ; C07D401/14 ; C07D405/12 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; C07D417/14 ; C07D487/04 ; C07D491/10 ; A61K31/45
摘要：
The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.
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