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1.发明公开
公开(公告)号：EP2049486A2
公开(公告)日：2009-04-22
申请号：EP07763650.4
申请日：2007-01-25
发明人： CARTER, Percy, H. , CAVALLARO, Cullen, L. , DUNCIA, John, V. , GARDNER, Daniel, S. , HYNES, John , LIU, Rui-qin , SANTELLA, Joseph, B. , DODD, Dharmpal, S.
IPC分类号： C07D211/18 , C07D211/38 , C07D211/52 , C07D211/58 , C07D211/70 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/10 , A61K31/45
CPC分类号： C07D211/52 , C07D211/18 , C07D211/38 , C07D211/58 , C07D211/70 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107
摘要： The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.
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公开(公告)号：EP1973880B1
公开(公告)日：2013-08-07
申请号：EP07710312.5
申请日：2007-01-25
IPC分类号： C07D213/56 , C07D295/18 , A61K31/4965 , A61P19/00
CPC分类号： C07D295/185 , C07D213/56
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公开(公告)号：EP1973880A1
公开(公告)日：2008-10-01
申请号：EP07710312.5
申请日：2007-01-25
IPC分类号： C07D213/56 , C07D295/18 , A61K31/4965 , A61P19/00
CPC分类号： C07D295/185 , C07D213/56
摘要： The present application describes modulators of MIP-1α of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein m, T, W, R1, R4, R5, R5a and R5b are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using said modulators are disclosed.
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