发明公开
- 专利标题： HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES
- 专利标题（中）： 杂芳基化合物作为E1活化酶的抑制剂
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申请号： EP07811106.9申请日： 2007-08-06
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公开(公告)号： EP2049491A1公开(公告)日： 2009-04-22
- 发明人: CLAIBORNE, Christopher, F. , CRITCHLEY, Stephen , LANGSTON, Steven, P. , OLHAVA, Edward, J. , PELUSO, Stephane , WEATHERHEAD, Gabriel, S. , VYSKOCIL, Stepan , VISIERS, Irache , MIZUTANI, Hirotake , CULLIS, Courtney
- 申请人： MILLENNIUM PHARMACEUTICALS, INC.
- 申请人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 专利权人： MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人： MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 代理机构： Harris, Jennifer Lucy
- 优先权： US836158P 20060808
- 国际公布： WO2008019124 20080214
- 主分类号： C07D213/82
- IPC分类号： C07D213/82 ; C07D239/48 ; C07D251/18 ; C07D403/04 ; C07D403/08 ; C07D473/32 ; C07D498/04 ; A61K31/505 ; A61P35/00
摘要：
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
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