发明公开
EP2057122A1 DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE 2 ADRENERGIC RECEPTOR
有权
4-(2-氨基-1-羟基乙基) - 苯酚衍生物作为2 - 肾上腺素能受体的激动剂
- 专利标题: DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE 2 ADRENERGIC RECEPTOR
- 专利标题(中): 4-(2-氨基-1-羟基乙基) - 苯酚衍生物作为2 - 肾上腺素能受体的激动剂
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申请号: EP07819060.0申请日: 2007-10-17
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公开(公告)号: EP2057122A1公开(公告)日: 2009-05-13
- 发明人: BACH TANA, Jordi , CRESPO CRESPO, Maria Isabel , PUIG DURAN, Carlos , GUAL ROIG, Silvia , ORTEGA MUÑOZ, Alberto
- 申请人: Laboratorios Almirall, S.A.
- 申请人地址: Ronda del General Mitre 151 08022 Barcelona ES
- 专利权人: Laboratorios Almirall, S.A.
- 当前专利权人: Laboratorios Almirall, S.A.
- 当前专利权人地址: Ronda del General Mitre 151 08022 Barcelona ES
- 代理机构: Srinivasan, Ravi Chandran
- 优先权: ES200602676 20061020
- 国际公布: WO2008046598 20080424
- 主分类号: C07D215/22
- IPC分类号: C07D215/22 ; C07C217/60 ; A61K31/435 ; A61K31/137 ; A61P9/00 ; A61P11/06 ; A61P29/00 ; A61P27/06
摘要:
The present invention provides a Compound of formula (I), wherein: R1 is a group selected from -CH2OH,-NH(CO)H; and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2; R3a and R3b are independently selected from the group consisting of hydrogen atoms and C1-4 alkyl groups; X and Y are independently selected from the group consisting of direct bond and oxygen atom; n, m and q each independently has a value selected from 0, 1, 2 and 3; p has a value selected from 1, 2 and 3; R4 and R5 are independently selected from hydrogen atoms, halogen atoms, C1-4 alkyl, C1-4 alkoxy, -CONH2, -NHCONH2, -SR7, -SOR7, -SO2R7, -SO2NHR8 and the groups (a) and (b), wherein R7 is selected from C1-4alkyl and C3-8 cycloalkyl and R8 is selected from hydrogen atoms and C1-4alkyl groups; R6 is selected from the group consisting of hydrogen atoms, halogen atoms, C1-4 alkyl and C1-4 alkoxy or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.
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