公开(公告)号：EP1885684A1

公开(公告)日：2008-02-13

申请号：EP06742964.7

申请日：2006-05-17

申请人： Laboratorios Almirall, S.A.

发明人： PUIG DURAN, Carlos ,  CRESPO CRESPO, Maria, Isabel ,  CASTRO PALOMINO LARIA, Julio, Cesar ,  GUAL ROIG, Silvia ,  NAVARRO ROMERO, Eloisa

IPC分类号： C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26 ,  C07D233/74 ,  A61K31/135 ,  A61K31/415 ,  A61K31/47 ,  A61P11/00

CPC分类号： C07D233/74 ,  C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26

摘要： The present invention provides a compound of formula (I) wherein: R1 is a group selected from -CH2OH, -NHC(O)H and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH- wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2; R3 is selected from hydrogen and halogen atoms or groups selected from -SO-R5, -SO2- R5, -NH-CO-NH2, -CO-NH2, hydantoino, C1-4alkyl, C1-4alkoxy and -SO2NR5R6; R4 is selected from hydrogen atoms, halogen atoms and C1-4alkyl groups; R5 is a C1-4alkyl group or C3-8 cycloalkyl; R6 is independently selected from hydrogen atoms and C1-4alkyl groups; n, p and q are independently 0, 1 , 2, 3 or 4; m and s are independently 0, 1 , 2 or 3; r is 0, 1 or 2; with the provisos that: at least one of m and r is not 0; the sum n+m+p+q+r+s is 7, 8, 9, 10, 11 , 12 or 13; the sum q+r+s is 2, 3, 4, 5 or 6 or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.

公开(公告)号：EP2057122A1

公开(公告)日：2009-05-13

申请号：EP07819060.0

申请日：2007-10-17

申请人： Laboratorios Almirall, S.A.

发明人： BACH TANA, Jordi ,  CRESPO CRESPO, Maria Isabel ,  PUIG DURAN, Carlos ,  GUAL ROIG, Silvia ,  ORTEGA MUÑOZ, Alberto

IPC分类号： C07D215/22 ,  C07C217/60 ,  A61K31/435 ,  A61K31/137 ,  A61P9/00 ,  A61P11/06 ,  A61P29/00 ,  A61P27/06

CPC分类号： C07D215/227 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4704 ,  A61K31/573 ,  A61K45/06 ,  C07C217/60 ,  C07C233/43

摘要： The present invention provides a Compound of formula (I), wherein: R1 is a group selected from -CH2OH,-NH(CO)H; and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2; R3a and R3b are independently selected from the group consisting of hydrogen atoms and C1-4 alkyl groups; X and Y are independently selected from the group consisting of direct bond and oxygen atom; n, m and q each independently has a value selected from 0, 1, 2 and 3; p has a value selected from 1, 2 and 3; R4 and R5 are independently selected from hydrogen atoms, halogen atoms, C1-4 alkyl, C1-4 alkoxy, -CONH2, -NHCONH2, -SR7, -SOR7, -SO2R7, -SO2NHR8 and the groups (a) and (b), wherein R7 is selected from C1-4alkyl and C3-8 cycloalkyl and R8 is selected from hydrogen atoms and C1-4alkyl groups; R6 is selected from the group consisting of hydrogen atoms, halogen atoms, C1-4 alkyl and C1-4 alkoxy or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.