公开(公告)号：EP4219445A1

公开(公告)日：2023-08-02

申请号：EP23162422.2

申请日：2020-03-06

申请人： Arbormentis LLC

发明人： MANFREDI, Paolo L. ,  INTURRISI, Charles E. ,  DE MARTIN, Sara ,  MATTAREI, Andrea ,  ROLANDO, Maurizio ,  GIORDANO, Giovanni ,  LODOVICHI, Claudia ,  BRUN, Paola ,  PAPPAGALLO, Marco ,  FOLLI, Franco ,  ALIMONTI, Andrea ,  SGRIGNANI, Jacopo ,  CAVALLI, Andrea

IPC分类号： C07C217/60 ,  C07D209/12 ,  A61K31/137 ,  A61K45/06

摘要： Compositions and methods of use comprising serotonin (5-HT) receptor agonists of formula (II) and NMDAR modulating substances, including especially certain substances classified as 5-HT2A agonists presently disclosed to exert NMDAR modulating effects, administered as modulators of neural plasticity, at non-psychedelic / psychotomimetic dosages, posology and formulations, for treatment of diseases and conditions and for improving functions (neuroplastogens).

公开(公告)号：EP3016931B1

公开(公告)日：2021-02-24

申请号：EP14738726.0

申请日：2014-06-19

发明人： KOFTIS, V. Theocharis ,  NEOKOSMIDIS, Efstratios ,  STATHAKIS, Christos ,  ANDREOU, Thanos ,  RAPTIS, Christos ,  VARVOGLI, Anastasia-Aikaterini

IPC分类号： C07C233/18 ,  C07C41/18 ,  C07C41/22 ,  C07C43/225 ,  C07C217/60 ,  C07C213/02 ,  C07C231/02

公开(公告)号：EP2990409B1

公开(公告)日：2019-12-25

申请号：EP14788170.0

申请日：2014-04-22

申请人： Kanto Kagaku Kabushiki Kaisha

发明人： WATANABE, Masahito ,  TAKEMOTO, Toshihide ,  TANAKA, Kouichi ,  MURATA, Kunihiko

IPC分类号： C07F15/00 ,  B01J31/22 ,  C07C209/28 ,  C07C211/27 ,  C07C211/29 ,  C07C211/35 ,  C07C211/40 ,  C07C211/42 ,  C07C213/02 ,  C07C215/08 ,  C07C217/60 ,  C07C227/08 ,  C07C227/32 ,  C07C229/14 ,  C07C253/30 ,  C07C255/58 ,  C07D213/38 ,  C07D213/42 ,  C07D217/14 ,  C07D277/28

公开(公告)号：EP2057122B1

公开(公告)日：2010-09-01

申请号：EP07819060.0

申请日：2007-10-17

申请人： Almirall, S.A.

发明人： BACH TANA, Jordi ,  CRESPO CRESPO, Maria Isabel ,  PUIG DURAN, Carlos ,  GUAL ROIG, Silvia ,  ORTEGA MUÑOZ, Alberto

IPC分类号： C07D215/22 ,  C07C217/60 ,  A61K31/435 ,  A61K31/137 ,  A61P9/00 ,  A61P11/06 ,  A61P29/00 ,  A61P27/06

CPC分类号： C07D215/227 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4704 ,  A61K31/573 ,  A61K45/06 ,  C07C217/60 ,  C07C233/43

摘要： The present invention provides a Compound of formula (I), wherein: R1 is a group selected from -CH2OH,-NH(CO)H; and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2; R3a and R3b are independently selected from the group consisting of hydrogen atoms and C1-4 alkyl groups; X and Y are independently selected from the group consisting of direct bond and oxygen atom; n, m and q each independently has a value selected from 0, 1, 2 and 3; p has a value selected from 1, 2 and 3; R4 and R5 are independently selected from hydrogen atoms, halogen atoms, C1-4 alkyl, C1-4 alkoxy, -CONH2, -NHCONH2, -SR7, -SOR7, -SO2R7, -SO2NHR8 and the groups (a) and (b), wherein R7 is selected from C1-4alkyl and C3-8 cycloalkyl and R8 is selected from hydrogen atoms and C1-4alkyl groups; R6 is selected from the group consisting of hydrogen atoms, halogen atoms, C1-4 alkyl and C1-4 alkoxy or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.

公开(公告)号：EP2212276A1

公开(公告)日：2010-08-04

申请号：EP08853662.8

申请日：2008-11-10

申请人： Almirall, S.A.

发明人： GIULIO MATASSA, Victor ,  PUIG DURAN, Carlos ,  PRAT QUIÑONES, Maria ,  SOLE FUE, Laia ,  LLERA SOLDEVILA, Oriol

IPC分类号： C07C217/60 ,  C07C223/02 ,  C07D215/24 ,  A61P9/00 ,  A61P15/06 ,  A61P25/00 ,  A61P27/06 ,  A61P29/00 ,  A61P11/06 ,  A61K31/4704 ,  A61K31/137

CPC分类号： C07D215/26 ,  C07C217/60 ,  C07C233/43 ,  C07C2603/74

摘要： The present invention provides a compound of formula (I): wherein: • R1 is a group selected from -CH2OH,-NH(CO)H and • R2 is a hydrogen atom; or • R1 together with R2 form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2 • R3a and R3b are independently selected from the group consisting of hydrogen atoms and C1-4alkyl groups, • n represents an integer from 1 to 3; • Ad represents 1-adamantyl or 2-adamantyl group, or a pharmaceutically-acceptable salt or solvate or stereoisomer thereof.

摘要翻译： 本公开涉及式（I）的4-（2-氨基-1-羟乙基）苯酚衍生物以及包含它们的药物组合物，以及它们在治疗中作为β肾上腺素能受体激动剂的用途。

公开(公告)号：EP1730103B1

公开(公告)日：2010-05-26

申请号：EP05708714.0

申请日：2005-03-10

申请人： Pfizer Limited ,  Pfizer Inc.

发明人： BROWN, Alan, Daniel ,  BUNNAGE, Mark, Edward ,  GLOSSOP, Paul, Alan ,  JAMES, Kim ,  LANE, Charlotte, Alice, Louise ,  LEWTHWAITE, Russell, Andrew ,  PRICE, David, Anthony

IPC分类号： C07C233/43 ,  C07C217/60 ,  A61K31/135

CPC分类号： C07C237/20 ,  C07C237/30 ,  C07C237/32 ,  C07C255/60 ,  C07C311/37 ,  C07C311/46 ,  C07C317/32 ,  C07C323/32 ,  C07C323/41 ,  C07C323/42 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2603/74 ,  C07D209/48 ,  C07D211/32 ,  C07D213/38 ,  C07D213/40 ,  C07D217/06 ,  C07D217/16 ,  C07D221/22 ,  C07D221/24 ,  C07D295/192 ,  C07D335/02

摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

摘要翻译： 本发明涉及式（1）的化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎性，过敏和呼吸道疾病，病症和病症。

公开(公告)号：EP1578353A4

公开(公告)日：2010-04-07

申请号：EP03726938

申请日：2003-05-19

申请人： SEQUELLA INC

发明人： PROTOPOPOVA MARINA NIKOLAEVNA ,  BOGATCHEVA ELENA

IPC分类号： A61K31/132 ,  A61K31/133 ,  A61K31/40 ,  A61K31/445 ,  C07C211/29 ,  C07C211/34 ,  C07C211/35 ,  C07C211/42 ,  C07C215/14 ,  C07C215/30 ,  C07C215/60 ,  C07C217/08 ,  C07C217/10 ,  C07C217/58 ,  C07C217/60 ,  C07C217/62 ,  C07C323/25 ,  C07C323/47 ,  C07D211/46 ,  A61K31/4545 ,  A61P31/06

CPC分类号： C07C323/25 ,  A61K31/132 ,  A61K31/133 ,  A61K31/40 ,  A61K31/445 ,  C07C211/29 ,  C07C211/34 ,  C07C211/35 ,  C07C211/42 ,  C07C215/14 ,  C07C215/30 ,  C07C215/60 ,  C07C217/08 ,  C07C217/10 ,  C07C217/58 ,  C07C217/60 ,  C07C217/62 ,  C07C323/47 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2602/42 ,  C07C2603/74 ,  C07D211/46

摘要： Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.

摘要翻译： 方法和组合物治疗疾病由传染性病原体引起的，特别是肺结核。 特别地，提供了包含substituiertem二胺传染性疾病的治疗方法和组合物。 在一个，实施例的合成方法和组合物用于分枝杆菌感染，包括治疗，但不限于，肺结核。

公开(公告)号：EP2064174A1

公开(公告)日：2009-06-03

申请号：EP07813996.1

申请日：2007-08-10

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： WAINER, Irving, W. ,  XIAO, Rui, Ping ,  ZHU, Weizhong ,  CHAKIR, Khalid ,  BEIGI, Farideh, M. ,  ABERNETHY, Darrell, R.

IPC分类号： C07C215/60 ,  C07C217/60 ,  A61K31/135 ,  A61P9/00 ,  A61P11/06

CPC分类号： C07C215/60

摘要： This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding &bgr;2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

公开(公告)号：EP1730103A1

公开(公告)日：2006-12-13

申请号：EP05708714.0

申请日：2005-03-10

申请人： Pfizer Limited ,  PFIZER INC.

发明人： BROWN, Alan, Daniel ,  BUNNAGE, Mark, Edward ,  GLOSSOP, Paul, Alan ,  JAMES, Kim ,  LANE, Charlotte, Alice, Louise ,  LEWTHWAITE, Russell, Andrew ,  PRICE, David, Anthony

IPC分类号： C07C233/43 ,  C07C217/60 ,  A61K31/135

CPC分类号： C07C237/20 ,  C07C237/30 ,  C07C237/32 ,  C07C255/60 ,  C07C311/37 ,  C07C311/46 ,  C07C317/32 ,  C07C323/32 ,  C07C323/41 ,  C07C323/42 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2603/74 ,  C07D209/48 ,  C07D211/32 ,  C07D213/38 ,  C07D213/40 ,  C07D217/06 ,  C07D217/16 ,  C07D221/22 ,  C07D221/24 ,  C07D295/192 ,  C07D335/02

摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

公开(公告)号：EP1675821A1

公开(公告)日：2006-07-05

申请号：EP04790756.3

申请日：2004-10-21

申请人： GLAXO GROUP LIMITED

发明人： BIGGADIKE, Keith

IPC分类号： C07C275/32 ,  C07C279/18 ,  C07C217/60 ,  C07C233/25 ,  C07C235/42 ,  C07C255/54 ,  C07D213/82 ,  C07D307/68 ,  C07C311/08 ,  C07C311/29 ,  C07C307/10 ,  C07C317/22 ,  A61K31/135 ,  A61K31/165 ,  A61K31/18

CPC分类号： C07C217/48 ,  C07C217/60 ,  C07C235/42 ,  C07C255/54 ,  C07C275/32 ,  C07C279/18 ,  C07C311/29 ,  C07C317/22 ,  C07C2601/08

摘要： Compounds of formula (I) and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β2-adrenoreceptor agonist is indicated, for example asthma or chronic obstructive pulmonary disease (COPD).

摘要翻译： 式（I）化合物及其盐，溶剂化物和生理学功能衍生物可用于预防或治疗选择性β2-肾上腺素受体激动剂所表现的临床病症，例如哮喘或慢性阻塞性肺病（COPD）。