发明公开
EP2074113A1 INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS
审中-公开
作为钾通道调节剂的合适的INDAZOLYLDERIVATE
- 专利标题: INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS
- 专利标题(中): 作为钾通道调节剂的合适的INDAZOLYLDERIVATE
-
申请号: EP07820871.7申请日: 2007-10-03
-
公开(公告)号: EP2074113A1公开(公告)日: 2009-07-01
- 发明人: ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , CHRISTOPHERSEN, Palle , JOHANSEN, Tina, Holm
- 申请人: NeuroSearch A/S
- 申请人地址: Pederstrupvej 93 2750 Ballerup DK
- 专利权人: NeuroSearch A/S
- 当前专利权人: NeuroSearch A/S
- 当前专利权人地址: Pederstrupvej 93 2750 Ballerup DK
- 代理机构: Madsen, Inger Margrethe Schelde
- 优先权: DK200601280 20061003; US827940P 20061003
- 国际公布: WO2008040753 20080410
- 主分类号: C07D403/04
- IPC分类号: C07D403/04 ; A61K31/4439 ; C07D401/04 ; A61K31/506 ; A61P9/00
摘要:
This invention relates to novel indazolyl derivatives of formula (Ia) and (Ib) useful as potassium channel modulating agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium- channels, in particular respiratory diseases, epilepsy, convulsions, seizures, absence seizures, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, erectile dysfunction, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart, disease, angina pectoris, coronary heart disease, autism, ataxia, traumatic brain injury, Parkinson's disease, bipolar disorder, psychosis, schizophrenia, anxiety, depression, mania, mood disorders, dementia, memory and attention deficits, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), dysmenorrhea,narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, arrhythmia, hypertension, myotonic muscle' dystrophia, spasticity, xerostomi, diabetes type II, hypehnsulinemia, premature labour, baldness, cancer, irritable bowel syndrome, immune suppression, migraine and pain.
信息查询