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    PYRIDINYL-QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE
    6.
    发明公开
    PYRIDINYL-QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE 有权
    PYRIDINYLCHINAZOLINDERIVATE及其医药用途

    公开(公告)号：EP1966184A2

    公开(公告)日：2008-09-10

    申请号：EP06841392.1

    申请日：2006-12-18

    申请人： NeuroSearch A/S

    发明人： ERIKSEN, Birgitte, L. ,  SØRENSEN, Ulrik, Svane ,  TEUBER, Lene ,  PETERS, Dan ,  HOUGAARD, Charlotte ,  JOHANSEN, Tina, Holm ,  CHRISTOPHERSEN, Palle

    IPC分类号： C07D401/04 ,  A61K31/517 ,  A61P11/06

    CPC分类号： C07D401/04

    摘要： This invention relates to novel pyridinyl-quinazoline derivatives of formula (I) and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels. n is 0, 1, 2 or 3; X represents O, S or NR'; wherein R' represents hydrogen, alky I, cycloalkyl or cycloalkyl-alkyl; or, when n is 0 and X is NR', R' together with Y and together with the nitrogen to which they are attached form a heterocyclic ring, which heterocyclic ring may optionally be substituted with alkyl of phenyl; Y represents alkyl, cycloalkyl, alkyl-cycloalkyl, alkenyl or phenyl, which phenyl is optionally substituted one or more times with substituents selected from the group consisting of alkyl, amino-alkyl, alkyl-amino, alkyl-amino-alkyl, hydroxy-alkyl, alkoxy-alkyl, cycloalkyl, cycloalkyl-alkyl, alkenyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, cyano, nitro and amino; or, when n is O, Y together with R' and together with the nitrogen to which they are attached form a heterocyclic ring, which heterocyclic ring may optionally be substituted with alkyl of phenyl; and R1, R2, R3 and R4, independently of each other, represent hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, alkenyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkoxy-carbonyl, cyano, nitro, amino, phenyl or benzoyl; or R1 and R2, or R2 and R3, or R3 and R4, respectively, together form a benzo-fused carbocyclic ring, optionally substituted with alkyl, cycloalkyl, cycloalkyl-alkyl, alkenyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkoxy-carbonyl, cyano, nitro, amino, phenyl or benzoyl; and the remaining of R1, R2, R3 and R4 represent hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, alkenyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy. alkoxy-carbonyl, cyano, nitro, amino, phenyl or benzoyl.