发明公开
- 专利标题： NUCLEIC ACID LIBRARIES AND THEIR DESIGN AND ASSEMBLY
- 专利标题（中）： NUCLEIC库及其设计与制造
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申请号： EP07839344.4申请日： 2007-10-04
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公开(公告)号： EP2078077A2公开(公告)日： 2009-07-15
- 发明人: BAYNES, Brian M. , DANNER, John P. , LIPOVSEK, Dasa , BASU, Subhayu
- 申请人： CODON DEVICES, INC
- 申请人地址： One Kendall Square, Building 300 Cambridge, MA 02139 US
- 专利权人： CODON DEVICES, INC
- 当前专利权人： CODON DEVICES, INC
- 当前专利权人地址： One Kendall Square, Building 300 Cambridge, MA 02139 US
- 代理机构： Trueman, Lucy Petra
- 优先权： US849558P 20061004; US876641P 20061221; US878331P 20061231
- 国际公布： WO2008045380 20080417
- 主分类号： C12N15/10
- IPC分类号： C12N15/10
摘要：
Aspects of the invention relate to the design and synthesis of nucleic acid libraries containing non-random mutations or variants. Aspects of the invention provide methods for assembling libraries containing high densities of predetermined variant sequences. Certain embodiments relate to the design and synthesis of nucleic acid libraries that express a predetermined polypeptide from a library of nucleic acids having silent sequence variants. Certain embodiments relate to the design and synthesis of nucleic acid libraries that express predetermined RNA variants that encode the same polypeptide sequence.
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