发明公开
- 专利标题： HYDRAZONE DERIVATIVE
- 专利标题（中）： 腙衍
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申请号： EP08703326.2申请日： 2008-01-09
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公开(公告)号： EP2105435A1公开(公告)日： 2009-09-30
- 发明人: TAKAMURO, Iwao , SUGAWARA, Kazutoshi , SUGAMA, Hiroshi
- 申请人： Mitsubishi Tanabe Pharma Corporation
- 申请人地址： 2-10, Dosho-machi 3-chome Chuo-ku Osaka-shi Osaka 541-8505 JP
- 专利权人： Mitsubishi Tanabe Pharma Corporation
- 当前专利权人： Mitsubishi Tanabe Pharma Corporation
- 当前专利权人地址： 2-10, Dosho-machi 3-chome Chuo-ku Osaka-shi Osaka 541-8505 JP
- 代理机构： Srinivasan, Ravi Chandran
- 优先权： JP2007002159 20070110
- 国际公布： WO2008084872 20080717
- 主分类号： C07D213/75
- IPC分类号： C07D213/75 ; A61K31/422 ; A61K31/427 ; A61K31/433 ; A61K31/437 ; A61K31/4439 ; A61K31/454 ; A61K31/455 ; A61K31/497 ; A61K31/4995 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; A61K31/55 ; A61K31/551 ; A61K31/553 ; A61K31/554 ; A61P27/02 ; A61P43/00
摘要：
A hydrazone derivative of formula [I]:
wherein Ring A is aryl or heteroaryl, Ring T is heteroaryl or heterocycle, R 1 and R 2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl, etc., R 3 and R 4 combine each other together with the adjacent nitrogen atom to form substituted or unsubstituted heterocycle, R 5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl, etc., and R 6 is hydrogen atom, etc.; or a pharmaceutically acceptable salt thereof is useful as a gluokinase activation agent.
wherein Ring A is aryl or heteroaryl, Ring T is heteroaryl or heterocycle, R 1 and R 2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl, etc., R 3 and R 4 combine each other together with the adjacent nitrogen atom to form substituted or unsubstituted heterocycle, R 5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl, etc., and R 6 is hydrogen atom, etc.; or a pharmaceutically acceptable salt thereof is useful as a gluokinase activation agent.
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