发明公开
- 专利标题： THIOPHENE CARBOXAMIDES AS FACTOR XA INHIBITORS
- 专利标题（中）： 硫代卡波酰胺阿司匹林XA-HEMMER
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申请号： EP08705691.7申请日： 2008-01-04
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公开(公告)号： EP2114928A2公开(公告)日： 2009-11-11
- 发明人: ZHU, Bing-yan , BAUER, Shawn M. , JIA, Zhaozhong J. , SONG, Yonghong , PROBST, Gary D. , ZHANG, Yanchen , SCARBOROUGH, Carroll
- 申请人： Millennium Pharmaceuticals, Inc.
- 申请人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 代理机构： Sexton, Jane Helen
- 优先权： US620615 20070105
- 国际公布： WO2008086188 20080717
- 主分类号： C07D409/12
- IPC分类号： C07D409/12 ; C07D409/14 ; C07D413/14 ; A61K31/4155 ; A61K31/4178 ; A61K31/4192 ; A61K31/421 ; A61P9/00
摘要：
The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
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