公开(公告)号：EP2114928A2

公开(公告)日：2009-11-11

申请号：EP08705691.7

申请日：2008-01-04

申请人： Millennium Pharmaceuticals, Inc.

发明人： ZHU, Bing-yan ,  BAUER, Shawn M. ,  JIA, Zhaozhong J. ,  SONG, Yonghong ,  PROBST, Gary D. ,  ZHANG, Yanchen ,  SCARBOROUGH, Carroll

IPC分类号： C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/421 ,  A61P9/00

CPC分类号： C07D409/14 ,  C07D333/38 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.