发明公开
EP2135952A2 Cripto antagonism of activin and TGF-beta signaling
审中-公开
Cripto-Antagonismus von Activin和TGF-β-Signalisierung
- 专利标题： Cripto antagonism of activin and TGF-beta signaling
- 专利标题（中）： Cripto-Antagonismus von Activin和TGF-β-Signalisierung
-
申请号： EP09009758.5申请日： 2004-09-14
-
公开(公告)号： EP2135952A2公开(公告)日： 2009-12-23
- 发明人: Vale, Wylie , Gray, Peter C. , Harrison, Craig Adam
- 申请人： RESEARCH DEVELOPMENT FOUNDATION
- 申请人地址： 402 North Division Street Carson City, Nevada 89703 US
- 专利权人： RESEARCH DEVELOPMENT FOUNDATION
- 当前专利权人： RESEARCH DEVELOPMENT FOUNDATION
- 当前专利权人地址： 402 North Division Street Carson City, Nevada 89703 US
- 代理机构： Dehmel, Albrecht
- 优先权： US503046P 20030915
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C07K14/71 ; A61K38/17
摘要：
Cripto, a developmental oncoprotein, antagonizes activin and TGF-β signaling by forming a complex with activin and TGF-β and their type II receptors. This complex precludes the formation of a functional activin/TGF-β•type II•type I complex, thereby blocking the signaling of activin and TGF-β. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-β complex may enhance antiproliferative effects of activin and TGF-β.
公开/授权文献
- EP2135952A3 Cripto antagonism of activin and TGF-beta signaling 公开/授权日：2010-09-29
信息查询
IPC分类:
