公开(公告)号：EP2135952A3

公开(公告)日：2010-09-29

申请号：EP09009758.5

申请日：2004-09-14

申请人： RESEARCH DEVELOPMENT FOUNDATION

发明人： Vale, Wylie ,  Gray, Peter C. ,  Harrison, Craig Adam

IPC分类号： C12N15/12 ,  C07K14/475 ,  A61K38/17

CPC分类号： C07K16/22 ,  C07K14/47 ,  C07K14/475 ,  C07K14/71 ,  C07K14/82

摘要： Cripto, a developmental oncoprotein, antagonizes activin and TGF-β signaling by forming a complex with activin and TGF-β and their type II receptors. This complex precludes the formation of a functional activin/TGF-β•type II•type I complex, thereby blocking the signaling of activin and TGF-β. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-β complex may enhance antiproliferative effects of activin and TGF-β.

公开(公告)号：EP2135952A2

公开(公告)日：2009-12-23

申请号：EP09009758.5

申请日：2004-09-14

申请人： RESEARCH DEVELOPMENT FOUNDATION

发明人： Vale, Wylie ,  Gray, Peter C. ,  Harrison, Craig Adam

IPC分类号： C12N15/12 ,  C07K14/71 ,  A61K38/17

CPC分类号： C07K16/22 ,  C07K14/47 ,  C07K14/475 ,  C07K14/71 ,  C07K14/82

摘要： Cripto, a developmental oncoprotein, antagonizes activin and TGF-β signaling by forming a complex with activin and TGF-β and their type II receptors. This complex precludes the formation of a functional activin/TGF-β•type II•type I complex, thereby blocking the signaling of activin and TGF-β. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-β complex may enhance antiproliferative effects of activin and TGF-β.

摘要翻译： Cripto是发育中的癌蛋白，通过与激活素和TGF-β2及其II型受体形成复合物拮抗激活素和TGF-β信号传导。 该复合物排除形成功能性激活素/ TGF-βII型复合物，从而阻断激活素和TGF-β的信号传导。 Cripto通常能够阻断抗增殖Smad2 / 3信号并提供具有多种治疗意义的致癌作用的新机制。 抑制Cripto和激活素/ TGF-β复合物的形成可增强激活素和TGF-β2的抗增殖作用。