发明公开
- 专利标题: CRYSTAL FORMS OF SAXAGLIPTIN AND PROCESSES FOR PREPARING SAME
- 专利标题(中): 沙格列汀结晶形式和方法及其
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申请号: EP08746183.6申请日: 2008-04-18
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公开(公告)号: EP2137149A2公开(公告)日: 2009-12-30
- 发明人: GOUGOUTAS, Jack Z. , MALLEY, Mary F. , DIMARCO, John D. , YIN, Xiaotian S. , WEI, Chenkou , YU, Jurong , VU, Truc Chi , JONES, Gregory Scott , SAVAGE, Scott A.
- 申请人: Bristol-Myers Squibb Company
- 申请人地址: Route 206 and Province Line Road P.O. Box 4000 Princeton, NJ 08543-4000 US
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: Route 206 and Province Line Road P.O. Box 4000 Princeton, NJ 08543-4000 US
- 代理机构: Reitstötter - Kinzebach
- 优先权: US912950P 20070420
- 国际公布: WO2008131149 20081030
- 主分类号: C07D209/52
- IPC分类号: C07D209/52 ; A61K31/403 ; A61P3/00
摘要:
Physical crystal structures of a compound of the formula (I): are provided including the free base monohydrate thereof (form H-1) and the hydrochloric acid salt thereof, including hydrochloric acid salt containing 0.75 equivalent of H2O (form H0.75-3) and hydrochloric acid salt containing 2 equivalents of H2O (form H2-1), and hydrochloric acid salt Pattern P-5, preferably in substantially pure form, and other forms as described herein, pharmaceutical compositions containing structures of compound I or IA, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
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