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公开(公告)号：EP2152717A1
公开(公告)日：2010-02-17
申请号：EP08769662.1
申请日：2008-05-23
发明人： PARLANTI, Luca , YU, Jurong
IPC分类号： C07D493/04 , C07D417/06
CPC分类号： C07D417/06 , A61K47/551 , A61K47/65 , C07D491/044 , C07D493/04 , C07K5/1021
摘要： The present invention relates to processes for making epothilone compounds and analogs thereof, such as epi-epothilone A or epi-epothilone B, and aziridinyl-epothilone analogs.
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2.发明公开Methods and compounds for producing dipeptidyl peptidase iv inhibitors and intermediates thereof 无效方法和组合物用于二肽基肽酶IV抑制剂中的用途以及它们的中间
公开(公告)号：EP2505579A3
公开(公告)日：2013-08-07
申请号：EP12162633.7
申请日：2003-12-04
发明人： VU, Truc, Chi , KOLOTUCHIN, Sergei, V. , MAZZULLO, John, A., Jr. , WANG, Jianji , WONG, Kwok , YU, Jurong , ZHU, Jason
IPC分类号： C07C62/06 , C07C229/28 , C07C271/22 , C07D207/22 , C07D209/52 , C07C69/635 , C07C69/675 , C07C69/757
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于生产二肽基肽酶IV的cycloproyl稠合的基于吡咯烷的抑制剂的方法和化合物。
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3.发明公开Methods and Compounds for Producing Dipeptidyl Peptidase IV Inhibitors and Intermediates thereof 有权生产二肽基肽酶IV抑制剂及其中间体的方法和化合物
公开(公告)号：EP2505578A3
公开(公告)日：2013-07-31
申请号：EP12162626.1
申请日：2003-12-04
发明人： VU, Truc, Chi , FOX, Rita , HANSON, Ronald, L. , MAZZULLO, John, A., Jr. , WANG, Jianji , YU, Jurong , MAGNIN, David, R. , HAMANN, Lawrence, G. , BRZOZOWSKI, David, B. , GODFREY, Jollie, Duaine, Jr. , KOLOTUCHIN, Sergei, V. , PATEL, Ramesh, N. , WONG, Kwok , ZHU, Jason , AUGERI, David, J.
IPC分类号： C07C62/06 , C07C229/28 , C07C271/22 , C07D207/22 , C07D209/52 , C07C69/635 , C07C69/675 , C07C69/757
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于生产二肽基肽酶IV的基于环丙酰基稠合吡咯烷的抑制剂的方法和化合物。
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4.发明公开Methods and compounds for producing dipeptidyl peptidase iv inhibitors and intermediates thereof 无效的方法和化合物用于制备它们的二肽基肽酶IV抑制剂和中间体的
公开(公告)号：EP2505579A2
公开(公告)日：2012-10-03
申请号：EP12162633.7
申请日：2003-12-04
发明人： VU, Truc, Chi , KOLOTUCHIN, Sergei, V. , MAZZULLO, John, A., Jr. , WANG, Jianji , WONG, Kwok , YU, Jurong , ZHU, Jason
IPC分类号： C07C62/06 , C07C229/28 , C07C271/22 , C07D207/22 , C07D209/52 , C07C69/635 , C07C69/675 , C07C69/757
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
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5.发明公开METHODS AND COMPOUNDS PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF 有权方法和化合物生产二肽基肽酶IV抑制剂及其中间体
公开(公告)号：EP1581487A2
公开(公告)日：2005-10-05
申请号：EP03812799.9
申请日：2003-12-04
发明人： VU, Truc, Chi , BRZOZOWSKI, David, B. , FOX, Rita , GODFREY, Jollie, Duaine, Jr. , HANSON, Ronald, L. , KOLOTUCHIN, Sergei, V. , MAZZULLO, John, A., Jr. , PATEL, Ramesh, N. , WANG, Jianji , WONG, Kwok , YU, Jurong , ZHU, Jason , MAGNIN, David, R. , AUGERI, David, J. , HAMANN, Lawrence, G.
IPC分类号： C07D201/00
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于生产二肽基肽酶IV的cycloproyl稠合的基于吡咯烷的抑制剂的方法和化合物。
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6.发明公开Methods and Compounds for Producing Dipeptidyl Peptidase IV Inhibitors and Intermediates thereof 有权的方法和化合物对二肽基肽酶IV抑制剂和其中间体的制备
公开(公告)号：EP2505578A2
公开(公告)日：2012-10-03
申请号：EP12162626.1
申请日：2003-12-04
发明人： VU, Truc, Chi , FOX, Rita , HANSON, Ronald, L. , MAZZULLO, John, A., Jr. , WANG, Jianji , YU, Jurong , MAGNIN, David, R. , HAMANN, Lawrence, G. , BRZOZOWSKI, David, B. , GODFREY, Jollie, Duaine, Jr. , KOLOTUCHIN, Sergei, V. , PATEL, Ramesh, N. , WONG, Kwok , ZHU, Jason , AUGERI, David, J.
IPC分类号： C07C62/06 , C07C229/28 , C07C271/22 , C07D207/22 , C07D209/52 , C07C69/635 , C07C69/675 , C07C69/757
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于生产二肽基肽酶IV的cycloproyl稠合的基于吡咯烷的抑制剂的方法和化合物。
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公开(公告)号：EP2137149A2
公开(公告)日：2009-12-30
申请号：EP08746183.6
申请日：2008-04-18
发明人： GOUGOUTAS, Jack Z. , MALLEY, Mary F. , DIMARCO, John D. , YIN, Xiaotian S. , WEI, Chenkou , YU, Jurong , VU, Truc Chi , JONES, Gregory Scott , SAVAGE, Scott A.
IPC分类号： C07D209/52 , A61K31/403 , A61P3/00
CPC分类号： C07D209/52 , A61K31/403 , A61K45/06 , A61K2300/00
摘要： Physical crystal structures of a compound of the formula (I): are provided including the free base monohydrate thereof (form H-1) and the hydrochloric acid salt thereof, including hydrochloric acid salt containing 0.75 equivalent of H2O (form H0.75-3) and hydrochloric acid salt containing 2 equivalents of H2O (form H2-1), and hydrochloric acid salt Pattern P-5, preferably in substantially pure form, and other forms as described herein, pharmaceutical compositions containing structures of compound I or IA, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
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