发明公开
EP2137158A1 SMALL MOLECULE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES (PRMTS)
审中-公开
蛋白质精氨酸甲基转移酶的小分子抑制剂（PRMTS）
- 专利标题： SMALL MOLECULE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES (PRMTS)
- 专利标题（中）： 蛋白质精氨酸甲基转移酶的小分子抑制剂（PRMTS）
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申请号： EP08714235.2申请日： 2008-02-28
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公开(公告)号： EP2137158A1公开(公告)日： 2009-12-30
- 发明人: WAHHAB, Amal , THERRIEN, Eric , ALLAN, Martin , MANKU, Sukhdev
- 申请人： MethylGene Inc.
- 申请人地址： 7220 Frederick-Banting St. Laurent, QC H4S 2A1 CA
- 专利权人： MethylGene Inc.
- 当前专利权人： MethylGene Inc.
- 当前专利权人地址： 7220 Frederick-Banting St. Laurent, QC H4S 2A1 CA
- 代理机构： Schnappauf, Georg
- 优先权： US892056P 20070228
- 国际公布： WO2008104077 20080904
- 主分类号： C07D231/14
- IPC分类号： C07D231/14 ; A61K31/415 ; A61K31/435 ; A61P31/00 ; A61P35/00 ; A61P37/00 ; C07D211/26 ; C07D231/22 ; C07D235/18 ; C07D401/00 ; C07D403/04 ; C07D403/12 ; C07D405/12 ; C07D409/04 ; C07D409/14 ; C07D413/04 ; C07D413/14 ; C07D417/04 ; C07D471/04 ; C07D487/04
摘要：
The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. Said compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.
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