发明公开
EP2155255A2 COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE
有权
组合物包含疏水性化合物和Polyaminosäurekonjugat
- 专利标题: COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE
- 专利标题(中): 组合物包含疏水性化合物和Polyaminosäurekonjugat
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申请号: EP08795840.1申请日: 2008-05-08
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公开(公告)号: EP2155255A2公开(公告)日: 2010-02-24
- 发明人: VAN, Sang , SONG, Yucheng , WANG, Xinghe , HOU, Zheng , FENG, Zhongling , ZHAO, Gang , YU, Lei
- 申请人: Nitto Denko Corporation
- 申请人地址: 1-1-2, Shimohozumi Ibaraki-shi, Osaka 567-8680 JP
- 专利权人: Nitto Denko Corporation
- 当前专利权人: Nitto Denko Corporation
- 当前专利权人地址: 1-1-2, Shimohozumi Ibaraki-shi, Osaka 567-8680 JP
- 代理机构: Miles, John Stephen
- 优先权: US916903P 20070509
- 国际公布: WO2008141107 20081120
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; A61K49/00 ; A61K49/12 ; A61K49/18 ; A61P35/00
摘要:
Various compositions that include a hydrophobic compound and a polymer conjugate are described herein. The compositions can include a polymer conjugate, a first hydrophobic drug, and a second hydrophobic drug. The polymer conjugates of the compositions described herein are capable of conjugating to a number of agents, such as imaging agents, targeting agents, stabilizing agents and/or drugs. Additionally, the polymer conjugates described herein can form nanoparticles that effectively solubilize the agent in an aqueous system by dispersing it at a molecular level, thus increasing the functionality and/or bioavailability of the agent. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications, including delivery of an agent to specific parts of the body.
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