公开(公告)号：EP1809331A2

公开(公告)日：2007-07-25

申请号：EP05796156.7

申请日：2005-09-14

申请人： NITTO DENKO CORPORATION

发明人： KITAURA, Chieko ,  MINOMI, Kenjiro ,  OKUBO, Katsuyuki ,  OKADA, Keisaku ,  KAGEHISA, Natsuko ,  KAMIYAMA, Masashi ,  HOU, Zheng ,  LIU, Jian ,  SONG, Yucheng ,  YU, Lei

IPC分类号： A61K47/48

CPC分类号： C07K14/605 ,  A61K9/0014 ,  A61K38/00 ,  A61K47/62 ,  A61K47/645 ,  C07K14/57563

摘要： Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is GLP-1, exendin or an analog of GLP-1 or exendin. The peptides with incretin hormone activity are administered transepithelially using a transepithelial carrier peptide. The transepithelial peptide contains sufficient amino, guanidine or amidino groups to stimulate transepithelial delivery. In some embodiments, the transepithelial carrier and the peptide with incretin hormone activity are embedded in a pressure sensitive adhesive layer of a plaster or patch.

公开(公告)号：EP2155255A2

公开(公告)日：2010-02-24

申请号：EP08795840.1

申请日：2008-05-08

申请人： Nitto Denko Corporation

发明人： VAN, Sang ,  SONG, Yucheng ,  WANG, Xinghe ,  HOU, Zheng ,  FENG, Zhongling ,  ZHAO, Gang ,  YU, Lei

IPC分类号： A61K47/48 ,  A61K49/00 ,  A61K49/12 ,  A61K49/18 ,  A61P35/00

CPC分类号： B82Y5/00 ,  A61K47/645 ,  A61K47/6925 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/146 ,  A61K49/1824

摘要： Various compositions that include a hydrophobic compound and a polymer conjugate are described herein. The compositions can include a polymer conjugate, a first hydrophobic drug, and a second hydrophobic drug. The polymer conjugates of the compositions described herein are capable of conjugating to a number of agents, such as imaging agents, targeting agents, stabilizing agents and/or drugs. Additionally, the polymer conjugates described herein can form nanoparticles that effectively solubilize the agent in an aqueous system by dispersing it at a molecular level, thus increasing the functionality and/or bioavailability of the agent. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications, including delivery of an agent to specific parts of the body.

公开(公告)号：EP2718261B1

公开(公告)日：2016-02-24

申请号：EP12728010.5

申请日：2012-06-08

申请人： Nitto Denko Corporation

发明人： SRIDHAR, C. Nagarajan ,  KARMALI, Priya ,  NIITSU, Yoshiro ,  PAYNE, Joseph E. ,  HOU, Zheng ,  GAUDETTE, John A. ,  KNOPOV, Victor ,  WITTE, Richard P. ,  AHMADIAN, Mohammad ,  PERELMAN, Loren A. ,  TANAKA, Yasunobu ,  AKOPIAN, Violetta

IPC分类号： C07C237/08 ,  A61K31/16 ,  A61P1/16 ,  C07C237/22 ,  C07C323/60 ,  C07C333/04 ,  A61K9/127

CPC分类号： C07C237/08 ,  A61K9/1271 ,  C07C237/22 ,  C07C323/60 ,  C07C333/04

公开(公告)号：EP2718261A2

公开(公告)日：2014-04-16

申请号：EP12728010.5

申请日：2012-06-08

申请人： Nitto Denko Corporation

发明人： SRIDHAR, C. Nagarajan ,  KARMALI, Priya ,  NIITSU, Yoshiro ,  PAYNE, Joseph E. ,  HOU, Zheng ,  GAUDETTE, John A. ,  KNOPOV, Victor ,  WITTE, Richard P. ,  AHMADIAN, Mohammad ,  PERELMAN, Loren A. ,  TANAKA, Yasunobu ,  AKOPIAN, Violetta

IPC分类号： C07C237/08 ,  A61K31/16 ,  A61P1/16 ,  C07C237/22 ,  C07C323/60 ,  C07C333/04

CPC分类号： C07C237/08 ,  A61K9/1271 ,  C07C237/22 ,  C07C323/60 ,  C07C333/04

摘要： Here described are compounds of formula I: wherein R
1 and R
2 is independently selected from a group consisting of C
10 to C
18 alkyl, C
12 to C
18 alkenyl, and oleyl group; wherein R
3 and R
4 are independently selected from a group consisting of C
1 to C
6 alkyl, and C
2 to C
6 alkanol; wherein X is selected from a group consisting of -CH
2 -, -S-, and -O- or absent; wherein Y is selected from -(CH
2 )n, -S(CH
2 )
n , -O(CH
2 )
n -, thiophene, -SO
2 (CH
2 )
n -, and ester, wherein n = 1 -4; wherein a = 1 -4; wherein b=l -4; wherein c=l-4; and wherein Z is a counterion; and compounds consisting of the structure (targeting molecule)
m -linker-(targeting molecule)
n , wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including one or both of these compounds which are useful for the delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.

公开(公告)号：EP2155255B1

公开(公告)日：2013-08-14

申请号：EP08795840.1

申请日：2008-05-08

申请人： Nitto Denko Corporation

发明人： VAN, Sang ,  SONG, Yucheng ,  WANG, Xinghe ,  HOU, Zheng ,  FENG, Zhongling ,  ZHAO, Gang ,  YU, Lei

IPC分类号： A61K47/48 ,  A61K49/00 ,  A61K49/08 ,  A61K49/14 ,  A61K49/18 ,  A61P35/00 ,  B82Y5/00

CPC分类号： B82Y5/00 ,  A61K47/645 ,  A61K47/6925 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/146 ,  A61K49/1824