- 专利标题: MONO-HYDROCHLORIC SALTS OF AN INHIBITOR OF HISTONE DEACETYLASE
- 专利标题(中): 单乙基脱乙酰壳多糖
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申请号: EP08750252.2申请日: 2008-05-13
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公开(公告)号: EP2155677A1公开(公告)日: 2010-02-24
- 发明人: DICKENS, Julius W.J. , HOUPIS, Ioannes Nicolaos , LANG, Yolande Lydia , LEYS, Carina , STOKBROEKX, Sigrid Carl Maria , WEERTS, Johan Erwin Edmond
- 申请人: Janssen Pharmaceutica, N.V.
- 申请人地址: Turnhoutseweg 30 2340 Beerse BE
- 专利权人: Janssen Pharmaceutica, N.V.
- 当前专利权人: Janssen Pharmaceutica, N.V.
- 当前专利权人地址: Turnhoutseweg 30 2340 Beerse BE
- 代理机构: Vandersteen, Pieter
- 优先权: EP07108176 20070514; US917821P 20070514
- 国际公布: WO2008138918 20081120
- 主分类号: C07D211/26
- IPC分类号: C07D211/26 ; C07D401/14 ; A61K31/506 ; A61P35/00
摘要:
This invention provides novel crystalline forms of mono-HCl salts and a mono-HCl salt hydrate of JNJ-26481585, an inhibitor of histone deacetylases. The invention also relates to processes for production of these forms, to intermediates used in these processes, to pharmaceutical compositions comprising these forms, and to the use of these forms in medical treatment for instance as a medicine to inhibit proliferative conditions, such as cancer and leukemia.
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