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1.发明公开IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS 有权咪唑并[1,2-B]吡啶并[DEREN] DEREN VERWENDUNG ALS PDE10-INHIBITOREN
公开(公告)号：EP2493889A1
公开(公告)日：2012-09-05
申请号：EP10768978.8
申请日：2010-10-27
发明人： PASTOR-FERNÁNDEZ, Joaquin , BARTOLOMÉ-NEBREDA, José, Manuel , MACDONALD, Gregor, James , CONDE-CEIDE, Susana , DELGADO-GONZÁLEZ, Óscar , VANHOOF, Greta, Constantia, Peter , VAN GOOL, Michiel, Luc, Maria , MARTÍN-MARTÍN, María, Luz , ALONSO-DE DIEGO, Sergio-Alvar , SWINNEY, Kelly, Ann , LEYS, Carina , WEERTS, Johan, Erwin, Edmond
IPC分类号： C07D487/04 , A61K31/5025 , A61P3/00 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel imidazo[1,2-b]pyridazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases.
摘要翻译： 本发明涉及作为磷酸二酯酶10酶（PDE10）的抑制剂的新的咪唑并[1,2-b]哒嗪衍生物，其可用于治疗或预防涉及PDE10酶的神经，精神和代谢紊乱 。 本发明还涉及包含这些化合物的药物组合物，以制备这些化合物和组合物以使用这些化合物或药物组合物来预防或治疗神经，精神和代谢疾病和疾病。
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2.发明授权IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS 有权咪唑并[1,2-b]哒嗪衍生物及其作为PDE10抑制剂的用途
公开(公告)号：EP2493889B1
公开(公告)日：2017-09-06
申请号：EP10768978.8
申请日：2010-10-27
发明人： PASTOR-FERNÁNDEZ, Joaquin , BARTOLOMÉ-NEBREDA, José, Manuel , MACDONALD, Gregor, James , CONDE-CEIDE, Susana , DELGADO-GONZÁLEZ, Óscar , VANHOOF, Greta, Constantia, Peter , VAN GOOL, Michiel, Luc, Maria , MARTÍN-MARTÍN, María, Luz , ALONSO-DE DIEGO, Sergio-Alvar , SWINNEY, Kelly, Ann , LEYS, Carina , WEERTS, Johan, Erwin, Edmond
IPC分类号： C07D487/04 , A61K31/5025 , A61P3/00 , A61P25/00
CPC分类号： C07D487/04
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3.发明授权Substituted phenylenediamines as inhibitors of the interaction between MDM2 and p53 有权取代的苯二胺作为MDM2与p53之间的相互作用的抑制剂
公开(公告)号：EP2185541B1
公开(公告)日：2015-01-28
申请号：EP08786899.8
申请日：2008-08-05
发明人： PONCELET, Alain Philippe , SCHOENTJES, Bruno , STORCK, Pierre-Henri , PONCELET, Virginie Sophie , LEYS, Carina
IPC分类号： C07D401/12 , A61K31/435 , A61K31/4045 , A61P35/00
CPC分类号： C07D401/12
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公开(公告)号：EP2155677B1
公开(公告)日：2014-10-01
申请号：EP08750252.2
申请日：2008-05-13
发明人： DICKENS, Julius W.J. , HOUPIS, Ioannes Nicolaos , LANG, Yolande Lydia , LEYS, Carina , STOKBROEKX, Sigrid Carl Maria , WEERTS, Johan Erwin Edmond
IPC分类号： C07D211/26 , C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： C07D211/26 , C07D401/14
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5.发明公开SUBSTITUTED PHENYLENEDIAMINES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 有权取代的苯二胺作为MDM2与p53之间的相互作用的抑制剂
公开(公告)号：EP2185541A1
公开(公告)日：2010-05-19
申请号：EP08786899.8
申请日：2008-08-05
发明人： PONCELET, Alain Philippe , SCHOENTJES, Bruno , STORCK, Pierre-Henri , PONCELET, Virginie Sophie , LEYS, Carina
IPC分类号： C07D401/12 , A61K31/435 , A61K31/4045 , A61P35/00
CPC分类号： C07D401/12
摘要： The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I).
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公开(公告)号：EP2155677A1
公开(公告)日：2010-02-24
申请号：EP08750252.2
申请日：2008-05-13
发明人： DICKENS, Julius W.J. , HOUPIS, Ioannes Nicolaos , LANG, Yolande Lydia , LEYS, Carina , STOKBROEKX, Sigrid Carl Maria , WEERTS, Johan Erwin Edmond
IPC分类号： C07D211/26 , C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： C07D211/26 , C07D401/14
摘要： This invention provides novel crystalline forms of mono-HCl salts and a mono-HCl salt hydrate of JNJ-26481585, an inhibitor of histone deacetylases. The invention also relates to processes for production of these forms, to intermediates used in these processes, to pharmaceutical compositions comprising these forms, and to the use of these forms in medical treatment for instance as a medicine to inhibit proliferative conditions, such as cancer and leukemia.
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