公开(公告)号：EP2155677B1

公开(公告)日：2014-10-01

申请号：EP08750252.2

申请日：2008-05-13

申请人： Janssen Pharmaceutica, N.V.

发明人： DICKENS, Julius W.J. ,  HOUPIS, Ioannes Nicolaos ,  LANG, Yolande Lydia ,  LEYS, Carina ,  STOKBROEKX, Sigrid Carl Maria ,  WEERTS, Johan Erwin Edmond

IPC分类号： C07D211/26 ,  C07D401/14 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D211/26 ,  C07D401/14

公开(公告)号：EP2155677A1

公开(公告)日：2010-02-24

申请号：EP08750252.2

申请日：2008-05-13

申请人： Janssen Pharmaceutica, N.V.

发明人： DICKENS, Julius W.J. ,  HOUPIS, Ioannes Nicolaos ,  LANG, Yolande Lydia ,  LEYS, Carina ,  STOKBROEKX, Sigrid Carl Maria ,  WEERTS, Johan Erwin Edmond

IPC分类号： C07D211/26 ,  C07D401/14 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D211/26 ,  C07D401/14

摘要： This invention provides novel crystalline forms of mono-HCl salts and a mono-HCl salt hydrate of JNJ-26481585, an inhibitor of histone deacetylases. The invention also relates to processes for production of these forms, to intermediates used in these processes, to pharmaceutical compositions comprising these forms, and to the use of these forms in medical treatment for instance as a medicine to inhibit proliferative conditions, such as cancer and leukemia.