发明公开
- 专利标题： METHOD FOR DETECTION OR TREATMENT OF GRAFT VERSUS HOST DISEASE
- 专利标题（中）： 检测或治疗移植物与宿主疾病的方法
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申请号： EP08764208.8申请日： 2008-06-23
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公开(公告)号： EP2163896A1公开(公告)日： 2010-03-17
- 发明人: HORI, Tsukasa , KOKAI, Yasuo , NAISHIRO, Yasuyoshi , TSUTSUMI, Hiroyuki , IMAI, Kohzoh
- 申请人： Sapporo Medical University , Immuno-Biological Laboratories Co., Ltd.
- 申请人地址： 291, Minami 1-jo Nishi 17-chome Chuo-ku Sapporo-shi Hokkaido 060-0061 JP
- 专利权人： Sapporo Medical University,Immuno-Biological Laboratories Co., Ltd.
- 当前专利权人： Sapporo Medical University,Immuno-Biological Laboratories Co., Ltd.
- 当前专利权人地址： 291, Minami 1-jo Nishi 17-chome Chuo-ku Sapporo-shi Hokkaido 060-0061 JP
- 代理机构： Nemec, Harald
- 优先权： JP2007165547 20070622
- 国际公布： WO2009001545 20081231
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; A61K39/395 ; A61P37/06 ; G01N27/62 ; G01N30/72 ; G01N30/88 ; G01N33/15 ; G01N33/50
摘要：
Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of CCL8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-CCL8 antibody is disclosed. The method of the present invention enables diagnosis of the onset of graft-versus-host disease and monitoring of the progress, in particular, differential diagnosis between graft-versus-host disease and an infectious disease. The present invention also provides a method for treating graft-versus-host disease utilizing the anti-CCL8 antibody.
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