摘要:
[Object] To provide an observation device capable of obtaining a good optical image by keeping contrast constant while eliminating the necessity of work for adjusting the distance from a phase contrast microscope to an observation target. [Solution] An observation device 10 includes a microscope 12. The microscope 12 includes an illumination light beam source 50, an illumination optical system 51, and an observation optical system 52 forming an optical image of an observation target 28 from reflected light beams 62 obtained by reflection of illumination light beams 61 by the observation target 28. The observation optical system 52 includes a phase plate 57 changing the phase of directly reflected light beams 62A reflected on a reflection surface 49a among the reflected light beams 62. Both the illumination optical system 51 and the observation optical system 52 are arranged under the observation target 28. The observation device 10 includes an image pickup device 53 photoelectrically converting the optical image obtained by the observation optical system 52 to create image data of the observation target 28 and a display device 38 displaying the image data. The illumination light beam 61 emitted from the illumination optical system 51 is a collimated light beam.
摘要:
Disclosed is a method for acquiring information on a condition of a patient with interstitial pneumonia, the method comprising measuring at least one biomarker in a biological sample of an interstitial pneumonia patient, the biomarker including at least one selected from CXCL9 and CXCL10, a measurement result of the biomarker serving as an index for discrimination between IPAF and CTD-ILD.
摘要:
Provided is a method for producing an antibody-drug conjugate comprising reacting a compound represented by the following formula:
(maleimid-N-yl)-(CH 2 )n 3 -C(=O)-L 2 -L P -NH-(CH 2 )n 1 -L a -(CH 2 )n 2 - C(=O)-(NH-DX)
with an anti-TROP2 antibody or a reactive derivative thereof and conjugating a drug-linker moiety to the antibody by a method for forming a thioether bond at a disulfide bond site present in a hinge part of the antibody.
摘要:
[Problem to be Solved] To provide a device for rehabilitation capable of giving a patient who cannot express an intention to voluntarily move the body a kinesthetic illusion that the his/her own body is moving and thus achieving a high rehabilitation effect, a rehabilitation system including it, a program for rehabilitation, and a rehabilitation method. [Solution] The device for rehabilitation includes: a biological signal acquisition unit 71 that acquires biological signals from a patient imparted with illusory stimulation for inducing a kinesthetic illusion; a characteristic biological signal detection unit 72 that analyzes the biological signals and detects a characteristic biological signal indicating a state where the kinesthetic illusion is induced; and a control signal output unit 73 that outputs control signals for controlling body driving means 4 and/or brain simulating means 5, when the characteristic biological signal is detected.
摘要:
It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L 1 -L 2 -L P -NH-(CH 2 )n 1 -L a -(CH 2 )n 2 -C(=O)- wherein the anti-TROP2 antibody is connected to the terminal of L 1 , and the antitumor compound is connected to the carbonyl group of the -(CH 2 )n 2 -C(=O)- moiety with the nitrogen atom of the amino group at position 1 as a connecting position.
摘要:
[Problem] To provide a neurogenic baroreflex sensitivity measurement device, neurogenic baroreflex sensitivity measurement program and neurogenic baroreflex sensitivity measurement method capable of easily and objectively measuring neurogenic baroreflex sensitivity that is not dependent on vascular hardness without using blood pressure or pulsations in the diameter of the carotid artery. [Solution] The neurogenic baroreflex sensitivity measurement device comprises: a pulse wave data-acquiring unit (41) for acquiring pulse wave data of an artery; a normalized pulse wave volume-calculating unit (42) for calculating a normalized pulse wave volume on the basis of the pulse wave data; a pulse interval-acquiring unit (43) for acquiring pulse intervals corresponding to the pulse wave data; a baroreflex series-detecting unit (44) for detecting baroreflex series in which the normalized pulse wave volume and pulse interval both increase or decrease for at least three beats in a row; and a neurogenic baroreflex sensitivity-calculating unit (45) for calculating the slope of a regression line representing the correlation between the normalized pulse wave volume and the pulse interval in a baroreflex series as the neurogenic baroreflex sensitivity, which is an index representing the neurogenic baroreflex function.
摘要:
[Problem] The purpose of the present invention is to provide a preparation which has an effect of further promoting cellular immunity when used in an adjuvant or in a method for removing an immunosuppression mechanism. [Solution] Provided is a sugar-coated liposome (particularly a mannose-coated liposome) which can activate a CTL in an MHC-class II antigen-independent (CD4+T cell-independent) manner when administered together with an MHC class I antigen. Particularly provided is a sugar-coated liposome which has a particle diameter of 100-1100 nm and/or in which the molar ratio of a sugar-modified lipid to a lipid is 0.00075-0.075.