发明公开
- 专利标题： GENOMIC EDITING IN ZEBRAFISH USING ZINC FINGER NUCLEASES
- 专利标题（中）： 斑马鱼的基因组编辑使用锌指核酸酶
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申请号： EP08833574.0申请日： 2008-09-25
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公开(公告)号： EP2205729A2公开(公告)日： 2010-07-14
- 发明人: AMACHER, Sharon , DOYON, Yannick , MCCAMMON, Jasmine , URNOV, Fyodor
- 申请人： Sangamo BioSciences, Inc. , The Regents of the University of California
- 申请人地址： Point Richmond Tech. Center 501 Canal Boulevard Suite A100 Richmond, CA 94804 US
- 专利权人： Sangamo BioSciences, Inc.,The Regents of the University of California
- 当前专利权人： Sangamo BioSciences, Inc.,The Regents of the University of California
- 当前专利权人地址： Point Richmond Tech. Center 501 Canal Boulevard Suite A100 Richmond, CA 94804 US
- 代理机构： Weiss, Wolfgang
- 优先权： US995577P 20070927; US68207P 20080305; US125817P 20080429
- 国际公布： WO2009042186 20090402
- 主分类号： C12N9/22
- IPC分类号： C12N9/22 ; C07K19/00 ; A01K67/027 ; C12N5/10 ; C12N15/55 ; C12N15/62
摘要：
Disclosed herein are methods and compositions for genomic editing of one or more genes in zebrafish, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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