发明公开
EP2209809A1 HUMAN MONOCLONAL ANTIBODIES DIRECTED TO SIALYL LEWIS C, SIALYL TN AND N-GLYCOLYLNEURAMINIC ACID EPITOPES AND A METHOD OF ANALYSIS OF STEM CELLS COMPRISING SAID EPITOPES
审中-公开
唾液酸基路易斯C，唾液酸Tn和N-羟表位的前瞻性人单克隆抗体以及用于干细胞与这些表位的调查方法
- 专利标题： HUMAN MONOCLONAL ANTIBODIES DIRECTED TO SIALYL LEWIS C, SIALYL TN AND N-GLYCOLYLNEURAMINIC ACID EPITOPES AND A METHOD OF ANALYSIS OF STEM CELLS COMPRISING SAID EPITOPES
- 专利标题（中）： 唾液酸基路易斯C，唾液酸Tn和N-羟表位的前瞻性人单克隆抗体以及用于干细胞与这些表位的调查方法
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申请号： EP08847066.1申请日： 2008-11-10
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公开(公告)号： EP2209809A1公开(公告)日： 2010-07-28
- 发明人: LAUKKANEN, Marja-Leena , TAKKINEN, Kristiina , NATUNEN, Jari , SATOMAA, Tero , PARKKINEN, Jaakko , VALMU, Leena , TIITINEN, Sari , NATUNEN, Suvi
- 申请人： Suomen Punainen Risti, Veripalvelu , Glykos Finland Oy
- 申请人地址： Kivihaantie 7 00310 Helsinki FI
- 专利权人： Suomen Punainen Risti, Veripalvelu,Glykos Finland Oy
- 当前专利权人： Suomen Punainen Risti, Veripalvelu,Glykos Finland Oy
- 当前专利权人地址： Kivihaantie 7 00310 Helsinki FI
- 代理机构： Karvinen, Leena Maria
- 优先权： FI20070853 20071109
- 国际公布： WO2009060129 20090514
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C12N15/13 ; C12P21/08 ; C40B30/04 ; G01N33/532 ; G01N33/563 ; G01N33/577 ; C12N5/08 ; C12N7/01
摘要：
This invention relates to antibody engineering technology. More particularly, the present invention relates to human IgM antibodies and derivatives thereof, which have novel binding specificity with regard to several oligosaccharide sequences and/or xenoantigenic sialic aicd residue. The present invention also relates to processes for making and engineering such novel saccharide and/or NeuGc-binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics, enabling qualitative and quantitative determination of xenoantigenic NeuGc in biological and raw material samples, as well as in immunotherapy, enabling blocking of xenoantigenic NeuGc in patients.
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