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1.发明公开SULPHATED HYALURONIC ACID IN COMBINATION WITH G-CSF FOR USE IN MOBILISING BLOOD STEM CELLS 审中-公开硫酸化的透明质酸与G-CSF组合使用IN造血干细胞的动员
公开(公告)号：EP2566486A1
公开(公告)日：2013-03-13
申请号：EP11723491.4
申请日：2011-05-06
发明人： NYSTEDT, Johanna , ANDERSON, Heidi , SATOMAA, Tero , NATUNEN, Jari , HELIN, Jari , SAARINEN, Juhani
IPC分类号： A61K31/728 , C07K14/535 , A61P7/00 , A61K31/198 , C08B37/00
CPC分类号： A61K31/198 , A61K31/728 , A61K38/193 , C07K14/535 , C08B37/0072 , C08L5/08 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention relates also to a use of the combination to alter the relative amounts of blood cells and/or the types of blood cells in a subject. Further, the present invention relates to a use of the combination to mobilize stem cells to the bloodstream of a subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
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2.发明公开NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开用于分析和修改的人类细胞组成和方法新碳水化合物谱
公开(公告)号：EP1945676A4
公开(公告)日：2012-06-27
申请号：EP06808024
申请日：2006-11-08
发明人： LAINE JARMO , SATOMAA TERO , NATUNEN JARI , HEISKANEN ANNAMARI , BLOMQVIST MARIA , OLONEN ANNE , SAARINEN JUHANI , JAATINEN TAINA , IMPOLA ULLA , MIKKOLA MILLA
CPC分类号： G01N33/66 , C07H13/04 , C08B37/006 , G01N2400/10
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公开(公告)号：EP2454594A1
公开(公告)日：2012-05-23
申请号：EP10744708.8
申请日：2010-07-14
IPC分类号： G01N33/569 , C12R1/225 , C12R1/13 , C12N5/071
CPC分类号： C12N1/20 , C12Q1/02 , G01N33/5008
摘要： The present invention relates to an in vitro and/or ex vivo method of screening probiotic bacterial strains. The present invention also relates to a method of assessing quality of probiotic culture. In addition, the present invention relates to use of animal cells in screening of a probiotic strain. The present invention also relates to use of animal cells in assessing quality of probiotic culture.
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4.发明公开ENZYMATICAL MODIF ICATION OF CELL GLYCOSYLATION USING SERUM ALBUMIN AND DIVALENT CATIONS 审中-公开基于血清白蛋白和双阳离子的细胞糖基化酶的修饰
公开(公告)号：EP2318540A4
公开(公告)日：2011-09-14
申请号：EP09797548
申请日：2009-07-16
发明人： NYSTEDT JOHANNA , ANDERSON HEIDI , VALMU LEENA , NATUNEN JARI , SATOMAA TERO
CPC分类号： C12N5/0006 , A61K2035/124 , C12N5/0663 , C12N5/0665 , C12N9/1051 , C12N2501/70 , C12N2501/724 , C12P21/005
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公开(公告)号：EP2115461A1
公开(公告)日：2009-11-11
申请号：EP08701719.0
申请日：2008-01-18
发明人： LAINE, Jarmo , SATOMAA, Tero , NATUNEN, Jari , HEISKANEN, Annamari , BLOMQVIST, Maria , OLONEN, Anne , SAARINEN, Juhani , TIITINEN, Sari , IMPOLA, Ulla , AITIO, Olli , VALMU, Leena , NATUNEN, Suvi , SALO, Hanna
CPC分类号： C07K16/28 , C07K16/2896 , C07K16/44 , G01N33/56966 , G01N2400/38
摘要： The invention describes reagents and methods for speficic binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
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6.发明公开Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells 审中-公开SulfatierteHyaluronsäurein Kombination mit G-CSFfürden Einsatz bei der Mobilisierung von Blutstammzellen
公开(公告)号：EP2384759A1
公开(公告)日：2011-11-09
申请号：EP10162117.5
申请日：2010-05-06
发明人： Nystedt, Johanna , Anderson, Heidi , Satomaa, Tero , Natunen, Jari , Helin, Jari , Saarinen, Juhani
IPC分类号： A61K31/728 , C07K14/535 , A61P7/00
CPC分类号： A61K31/198 , A61K31/728 , A61K38/193 , C07K14/535 , C08B37/0072 , C08L5/08 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention relates also to a use of the combination to alter the relative amounts of blood cells and/or the types of blood cells in a subject. Further, the present invention relates to a use of the combination to mobilize stem cells to the bloodstream of a subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
摘要翻译： 本发明涉及透明质酸低聚物和/或聚合物的组合以及能够动员干细胞的因子。 本发明还涉及组合物用于改变受试者血细胞相对量和/或血细胞类型的用途。 此外，本发明涉及组合物用于将干细胞移动到受试者的血流中的用途。 另外，本发明涉及透明质酸低聚物和/或聚合物。
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公开(公告)号：EP2315828A2
公开(公告)日：2011-05-04
申请号：EP09784152.2
申请日：2009-07-13
发明人： IMPOLA, Ulla , TIITTANEN, Minna , MIKKOLA, Milla , PARTANEN, Jukka , NATUNEN, Jari , SATOMAA, Tero , SAARINEN, Juhani
IPC分类号： C12N5/0735 , C07K14/47
CPC分类号： C12N15/873 , C12N5/0606 , C12N5/0696 , C12N2500/90 , C12N2501/115 , C12N2533/50
摘要： The invention relates to a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) cells on a lectin. The invention relates also to the use of a lectin in a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) celts and a culture medium composition containing a lectin attached on the culturing plates.
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8.发明公开HUMAN MONOCLONAL ANTIBODIES DIRECTED TO SIALYL LEWIS C, SIALYL TN AND N-GLYCOLYLNEURAMINIC ACID EPITOPES AND A METHOD OF ANALYSIS OF STEM CELLS COMPRISING SAID EPITOPES 审中-公开唾液酸基路易斯C，唾液酸Tn和N-羟表位的前瞻性人单克隆抗体以及用于干细胞与这些表位的调查方法
公开(公告)号：EP2209809A4
公开(公告)日：2011-03-30
申请号：EP08847066
申请日：2008-11-10
发明人： LAUKKANEN MARJA-LEENA , TAKKINEN KRISTIINA , NATUNEN JARI , SATOMAA TERO , PARKKINEN JAAKKO , VALMU LEENA , TIITINEN SARI , NATUNEN SUVI
IPC分类号： C07K16/28 , C12N7/01 , C12N15/13 , C12P21/08 , C40B30/04 , G01N33/532 , G01N33/563 , G01N33/577 , C12N5/08
CPC分类号： C07K16/3076 , C07K2317/21 , C07K2317/622 , G01N33/56966 , G01N2400/10
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公开(公告)号：EP2166085A1
公开(公告)日：2010-03-24
申请号：EP08397517.7
申请日：2008-07-16
IPC分类号： C12N5/07
CPC分类号： C12N5/0006 , A61K2035/124 , C12N5/0663 , C12N5/0665 , C12N9/1051 , C12N2501/70 , C12N2501/724 , C12P21/005
摘要： The invention is directed to a method and composition to control and modify the status of human stem cells by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where divalent cations are present and cells are kept non-adherent. The invention is further directed to the stem cell population so obtained, the glycosylation of which has been specifically altered.
摘要翻译： 本发明涉及一种方法和组合物，其通过在存在二价阳离子且细胞保持不粘附的反应条件下改变其糖基化，特别是唾液酸化和岩藻糖基化水平来控制和修饰人类干细胞的状态。 本发明进一步针对如此获得的干细胞群，其糖基化被特异性地改变。
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公开(公告)号：EP1891437A2
公开(公告)日：2008-02-27
申请号：EP06764482.3
申请日：2006-06-06
发明人： JAATINEN, Taina , HEMMORANTA, Heidi , PARTANEN, Jukka , LAINE, Jarmo , SATOMAA, Tero , NATUNEN, Jari , BLOMQVIST, Maria
IPC分类号： G01N33/50 , G01N33/567 , G01N33/577 , C12N5/06 , C12Q1/68 , C07H3/06
CPC分类号： G01N33/5308 , G01N33/5002 , G01N33/56966
摘要： The present invention relates to a method of profiling a cell population comprising a step of detecting the presence or absence of at least two biological markers in said cell population, wherein at least one of said markers is a cell surface marker, which is a sialylated N-glycan marker with structure NeuNAcα3Gal, and at least one of said markers is a mRNA marker related to glycoproteins and/or glycosynthase proteins. The invention also relates to method for purification of cord blood cell population and to a complete cell population from cord blood purified by said method.
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