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1.发明公开SULPHATED HYALURONIC ACID IN COMBINATION WITH G-CSF FOR USE IN MOBILISING BLOOD STEM CELLS 审中-公开硫酸化的透明质酸与G-CSF组合使用IN造血干细胞的动员
公开(公告)号：EP2566486A1
公开(公告)日：2013-03-13
申请号：EP11723491.4
申请日：2011-05-06
发明人： NYSTEDT, Johanna , ANDERSON, Heidi , SATOMAA, Tero , NATUNEN, Jari , HELIN, Jari , SAARINEN, Juhani
IPC分类号： A61K31/728 , C07K14/535 , A61P7/00 , A61K31/198 , C08B37/00
CPC分类号： A61K31/198 , A61K31/728 , A61K38/193 , C07K14/535 , C08B37/0072 , C08L5/08 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention relates also to a use of the combination to alter the relative amounts of blood cells and/or the types of blood cells in a subject. Further, the present invention relates to a use of the combination to mobilize stem cells to the bloodstream of a subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
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公开(公告)号：EP2047257A1
公开(公告)日：2009-04-15
申请号：EP07788780.0
申请日：2007-06-29
发明人： LAINE, Jarmo , SATOMAA, Tero , NATUNEN, Jari , HEISKANEN, Annamari , SAARINEN, Juhani , JAATINEN, Taina , MIKKOLA, Milla , NATUNEN, Suvi
CPC分类号： G01N33/6848 , C08B37/0006 , C08B37/006 , C12N5/0606 , G01N33/56966 , G01N2400/10
摘要： The invention describes novel compositions of glycans, glycomes, from human embryonic stem cells, and especially novel subcompositions of the glycomes with specific monosaccharide compositions and glycan structures. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore, the invention is directed to stem cells carrying the modified glycomes on their surfaces. The glycomes are preferably analysed by profiling methods able to detect reproducibly and quantitatively numerous individual glycan structures at the same time. The most preferred type of the profile is a mass spectrometric profile. The invention specifically revealed novel target structures and is especially directed to the development of reagents recognizing the structures.
摘要翻译： 本发明描述了来自人胚胎干细胞的聚糖，糖类的新型组合物，尤其是具有特定单糖组成和聚糖结构的糖类的新型亚组合物。 本发明还涉及修饰糖类和糖类和修饰糖类分析的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。 优选通过分析方法分析糖类，所述方法能够同时检测可重复和定量的多种单独的聚糖结构。 该配置文件的最优选类型是质谱配置文件。 本发明具体揭示了新颖的靶结构并且特别针对开发识别结构的试剂。
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公开(公告)号：EP2315828A2
公开(公告)日：2011-05-04
申请号：EP09784152.2
申请日：2009-07-13
发明人： IMPOLA, Ulla , TIITTANEN, Minna , MIKKOLA, Milla , PARTANEN, Jukka , NATUNEN, Jari , SATOMAA, Tero , SAARINEN, Juhani
IPC分类号： C12N5/0735 , C07K14/47
CPC分类号： C12N15/873 , C12N5/0606 , C12N5/0696 , C12N2500/90 , C12N2501/115 , C12N2533/50
摘要： The invention relates to a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) cells on a lectin. The invention relates also to the use of a lectin in a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) celts and a culture medium composition containing a lectin attached on the culturing plates.
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公开(公告)号：EP1891437A2
公开(公告)日：2008-02-27
申请号：EP06764482.3
申请日：2006-06-06
发明人： JAATINEN, Taina , HEMMORANTA, Heidi , PARTANEN, Jukka , LAINE, Jarmo , SATOMAA, Tero , NATUNEN, Jari , BLOMQVIST, Maria
IPC分类号： G01N33/50 , G01N33/567 , G01N33/577 , C12N5/06 , C12Q1/68 , C07H3/06
CPC分类号： G01N33/5308 , G01N33/5002 , G01N33/56966
摘要： The present invention relates to a method of profiling a cell population comprising a step of detecting the presence or absence of at least two biological markers in said cell population, wherein at least one of said markers is a cell surface marker, which is a sialylated N-glycan marker with structure NeuNAcα3Gal, and at least one of said markers is a mRNA marker related to glycoproteins and/or glycosynthase proteins. The invention also relates to method for purification of cord blood cell population and to a complete cell population from cord blood purified by said method.
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5.发明公开A METHOD OF EVALUATING THE INTEGRITY OF THE PLASMA MEMBRANE OF CELLS BY DETECTING GLYCANS FOUND ONLY INTRACELLULARLY 审中-公开评估方法质膜细胞的完整性仅INTREZELLULÄR经过验证的聚糖
公开(公告)号：EP2316028A1
公开(公告)日：2011-05-04
申请号：EP09797547.8
申请日：2009-07-16
发明人： HIRVONEN, Tia , KOTOVUORI, Annika , PITKÄNEN, Virve , NATUNEN, Suvi , NYSTEDT, Johanna , TIITINEN, Sari , VALMU, Leena , NATUNEN, Jari
IPC分类号： G01N33/53 , G01N33/563 , G01N33/577 , C07H13/00
CPC分类号： G01N33/5308 , G01N33/56966 , G01N2400/12 , G01N2400/38
摘要： The invention describes novel reagents that can be applied for analysis of the quality of human cells. The method evaluates the integrity of the plasma membrane of the cells by detecting novel glyco structures found only intracellularly. The method can be applied, for example, to demonstrate exposure of therapeutic cell preparation to potentially harmful conditions. It can also be used as a quality control tool in methods in which intact cell membrane is essential and it can be applied in separation of damaged cells from non- damaged.
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6.发明公开HUMAN MONOCLONAL ANTIBODIES DIRECTED TO SIALYL LEWIS C, SIALYL TN AND N-GLYCOLYLNEURAMINIC ACID EPITOPES AND A METHOD OF ANALYSIS OF STEM CELLS COMPRISING SAID EPITOPES 审中-公开唾液酸基路易斯C，唾液酸Tn和N-羟表位的前瞻性人单克隆抗体以及用于干细胞与这些表位的调查方法
公开(公告)号：EP2209809A1
公开(公告)日：2010-07-28
申请号：EP08847066.1
申请日：2008-11-10
发明人： LAUKKANEN, Marja-Leena , TAKKINEN, Kristiina , NATUNEN, Jari , SATOMAA, Tero , PARKKINEN, Jaakko , VALMU, Leena , TIITINEN, Sari , NATUNEN, Suvi
IPC分类号： C07K16/28 , C12N15/13 , C12P21/08 , C40B30/04 , G01N33/532 , G01N33/563 , G01N33/577 , C12N5/08 , C12N7/01
CPC分类号： C07K16/3076 , C07K2317/21 , C07K2317/622 , G01N33/56966 , G01N2400/10
摘要： This invention relates to antibody engineering technology. More particularly, the present invention relates to human IgM antibodies and derivatives thereof, which have novel binding specificity with regard to several oligosaccharide sequences and/or xenoantigenic sialic aicd residue. The present invention also relates to processes for making and engineering such novel saccharide and/or NeuGc-binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics, enabling qualitative and quantitative determination of xenoantigenic NeuGc in biological and raw material samples, as well as in immunotherapy, enabling blocking of xenoantigenic NeuGc in patients.
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7.发明公开NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开用于分析和修改的人类细胞组成和方法新碳水化合物谱
公开(公告)号：EP1945676A1
公开(公告)日：2008-07-23
申请号：EP06808024.1
申请日：2006-11-08
发明人： LAINE, Jarmo , SATOMAA, Tero , NATUNEN, Jari , HEISKANEN, Annamari , BLOMQVIST, Maria , OLONEN, Anne , SAARINEN, Juhani , JAATINEN, Taina , IMPOLA, Ulla , MIKKOLA, Milla
CPC分类号： G01N33/66 , C07H13/04 , C08B37/006 , G01N2400/10
摘要： The present invention discloses a method of evaluating the status of a stem cell preparation comprising the step of detecting the presence of a glycan structure or a group of glycan structures in said preparation. The detection step can be performed by the use of a lectin specific to a glycan structure of interest.
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公开(公告)号：EP1904851A2
公开(公告)日：2008-04-02
申请号：EP06778519.6
申请日：2006-07-07
发明人： LAINE, Jarmo , JAATINEN, Taina , ANDERSON, Heidi , NYSTEDT, Johanna , TIITINEN, Sari , LAITINEN, Anita , IMPOLA, Ulla , SATOMAA, Tero , NATUNEN, Jari , HEISKANEN, Annamari , BLOMQVIST, Maria , OLONEN, Anne
IPC分类号： G01N33/569 , C12N5/06
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人类干细胞上的特定唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其特异性改变的糖基化的新型干细胞。
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9.发明公开NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开来自人细胞的新型碳水化合物特征组合物及其分析和修饰方法
公开(公告)号：EP1904532A2
公开(公告)日：2008-04-02
申请号：EP06764561.4
申请日：2006-07-11
发明人： SATOMAA, Tero , NATUNEN, Jari , LAINE, Jarmo , HEISKANEN, Annamari , BLOMQVIST, Maria , OLONEN, Anne , SAARINEN, Juhani , JAATINEN, Taina , IMPOLA, Ulla , MIKKOLA, Milla , HEMMORANTA, Heidi
CPC分类号： C12N5/0665 , C08B37/00 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/59 , G01N33/56966 , G01N33/574 , G01N33/57469 , G01N33/577 , G01N2400/10 , G01N2400/38 , G01N2560/00
摘要： The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
摘要翻译： 本发明描述了用于从人多能干细胞产生新的糖链聚糖组合物的方法。 本发明还涉及修饰糖类和糖类和修饰糖类分析的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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公开(公告)号：EP2115461A1
公开(公告)日：2009-11-11
申请号：EP08701719.0
申请日：2008-01-18
发明人： LAINE, Jarmo , SATOMAA, Tero , NATUNEN, Jari , HEISKANEN, Annamari , BLOMQVIST, Maria , OLONEN, Anne , SAARINEN, Juhani , TIITINEN, Sari , IMPOLA, Ulla , AITIO, Olli , VALMU, Leena , NATUNEN, Suvi , SALO, Hanna
CPC分类号： C07K16/28 , C07K16/2896 , C07K16/44 , G01N33/56966 , G01N2400/38
摘要： The invention describes reagents and methods for speficic binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
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