发明公开
EP2229373A1 SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY
审中-公开
取代的2-NAPHTOESÄURENAS GPR105活性拮抗剂
- 专利标题： SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY
- 专利标题（中）： 取代的2-NAPHTOESÄURENAS GPR105活性拮抗剂
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申请号： EP08856275.6申请日： 2008-12-01
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公开(公告)号： EP2229373A1公开(公告)日： 2010-09-22
- 发明人: BELLEY, Michel , DESCHENES, Denis , FORTIN, Rejean , FOURNIER, Jean-Francois , GAGNE, Sebastien , GAREAU, Yves , GAUTHIER, Jacques, Yves , LI, Lianhai , ROBICHAUD, Joel , THERIEN, Michel , TRANMER, Geoffrey, K. , WANG, Zhaoyin
- 申请人： Merck Frosst Canada Ltd.
- 申请人地址： 16711 Trans-Canada Highway Kirkland, Québec H9H 3L1 CA
- 专利权人： Merck Frosst Canada Ltd.
- 当前专利权人： Merck Frosst Canada Ltd.
- 当前专利权人地址： 16711 Trans-Canada Highway Kirkland, Québec H9H 3L1 CA
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US5266 20071204
- 国际公布： WO2009070873 20090611
- 主分类号： C07D333/24
- IPC分类号： C07D333/24 ; A61K31/192 ; A61K31/381 ; A61P3/04 ; A61P3/10 ; C07C65/11 ; C07C65/24 ; C07C63/36 ; C07C69/76 ; C07D317/60 ; C07D249/08 ; C07D211/34 ; C07C317/44 ; C07C323/62 ; C07C65/30 ; C07C65/34 ; C07D211/52 ; C07D333/34
摘要：
Substituted 2-naphthoic acids of structural formula I are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.
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