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1.发明公开FLUORO-METHANESULFONYL-SUBSTITUTED CYCLOALKANOINDOLES AND THEIR USE AS PROSTAGLANDIN D2 ANTAGONISTS 审中-公开氟甲磺酰基取代CYCLOALKANOINDOLE FOR USE前列腺素D2拮抗剂
公开(公告)号：EP1631547A1
公开(公告)日：2006-03-08
申请号：EP04733516.1
申请日：2004-05-18
IPC分类号： C07D209/94 , C07D209/88 , A61K31/403 , A61P11/02 , A61P11/06
CPC分类号： C07D209/88 , C07D209/94
摘要： Novel cycloalkanoindole derivatives of formula (I) are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.
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2.发明授权FLUORO SUBSTITUTED CYCLOALKANOINDOLES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 有权氟取代CYCLOALKANINDOLE及其作为前列腺素D2受体拮抗剂
公开(公告)号：EP1470107B1
公开(公告)日：2008-11-19
申请号：EP03700740.8
申请日：2003-01-22
IPC分类号： C07D209/80 , A61K31/403 , A61P43/00 , C07D209/88
CPC分类号： C07D209/80 , C07D209/88
摘要： Fluoro substituted cycloalkanoindole derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein n is 0 or 1; m is 1, 2 or 3; R1 is H, C1-C3 alkyl, halogenated C1-C3 alkyl or cyclopropyl; R2 is 4-chlorophenyl or 2,4,6-trichlorophenyl are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.
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3.发明公开SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY 审中-公开取代的2-NAPHTOESÄURENAS GPR105活性拮抗剂
公开(公告)号：EP2229373A1
公开(公告)日：2010-09-22
申请号：EP08856275.6
申请日：2008-12-01
发明人： BELLEY, Michel , DESCHENES, Denis , FORTIN, Rejean , FOURNIER, Jean-Francois , GAGNE, Sebastien , GAREAU, Yves , GAUTHIER, Jacques, Yves , LI, Lianhai , ROBICHAUD, Joel , THERIEN, Michel , TRANMER, Geoffrey, K. , WANG, Zhaoyin
IPC分类号： C07D333/24 , A61K31/192 , A61K31/381 , A61P3/04 , A61P3/10 , C07C65/11 , C07C65/24 , C07C63/36 , C07C69/76 , C07D317/60 , C07D249/08 , C07D211/34 , C07C317/44 , C07C323/62 , C07C65/30 , C07C65/34 , C07D211/52 , C07D333/34
CPC分类号： C07D211/34 , C07C65/24 , C07C65/30 , C07C65/40 , C07C69/76 , C07C69/94 , C07C317/44 , C07C317/46 , C07C323/62 , C07D211/52 , C07D249/08 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/34 , C07D487/04
摘要： Substituted 2-naphthoic acids of structural formula I are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.
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4.发明公开NOVEL SUBSTITUTED 1,2,3-T II AZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOTIIENE BIOSYNTHESIS INHIBITORS 审中-公开新的取代1,2,3- TRIAZOLYLMETHYLBENZOTHIOPHENE或ENDOLE及其作为抑制剂白三烯生物合成
公开(公告)号：EP1915369A1
公开(公告)日：2008-04-30
申请号：EP06775086.9
申请日：2006-08-08
发明人： BERTHELETTE, Carl , DUFRESNE,Claude , LI, Lianhai , WANG, Zhaoyin
IPC分类号： C07D409/06 , A61P9/10 , A61K31/4192 , A61P11/06 , A61P29/00 , C07D403/06 , C07D409/14
CPC分类号： C07D403/06 , C07D409/06 , C07D409/14 , C07D413/14
摘要： The instant invention provides compounds of Formula I which are leukotπene biosynthesis inhibitors. Z is a fused (optionally sulfo-oxidized) thiophen ring or a fused pyrrol ring R2-R4 are selected from a variety of substituents Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti¬ inflammatory and cytoprotective agents.
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公开(公告)号：EP2170883A1
公开(公告)日：2010-04-07
申请号：EP08772860.6
申请日：2008-06-26
发明人： GUAY, Daniel , BEAULIEU, Christian , BELLEY, Michel , CRANE, Sheldon, N. , DE LUCA, Jeancarlo , FORTIN, Rejean , GAREAU, Yves , LI, Lianhai , THERIEN, Michel , TRANMER, Geoffrey, K. , TRUONG, Vouy, Linh , WANG, Zhaoyin
IPC分类号： C07D471/04 , A61K31/519 , A61P3/00
CPC分类号： C07D471/04
摘要： Fused pyrimidine compounds of structural formula (I) are effective as antagonists of the biological activity of the GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and Metabolic Syndrome.
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