发明公开
EP2245055A2 POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS
审中-公开
多肽和多核苷酸及其用作药物靶标制毒化和生物制品
- 专利标题： POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS
- 专利标题（中）： 多肽和多核苷酸及其用作药物靶标制毒化和生物制品
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申请号： EP09706816.7申请日： 2009-02-01
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公开(公告)号： EP2245055A2公开(公告)日： 2010-11-03
- 发明人: LEVIN, Zurit , ROSENBERG, Avi Yeshah , ROTMAN, Galit , TOPORIK, Amir , DASSA, Liat , BEIMAN, Merav , LEVY, Ofer , NEMZAR, Sergey , WALACH, Shira , SAMEACH-GREENWALD, Shirley , MONTIA, Eve , KINAR, Yaron , COHEN-DAYAG, Anat
- 申请人： Compugen Ltd.
- 申请人地址： Pinchas Rosen Street 72 69512 Tel Aviv IL
- 专利权人： Compugen Ltd.
- 当前专利权人： Compugen Ltd.
- 当前专利权人地址： Pinchas Rosen Street 72 69512 Tel Aviv IL
- 代理机构： Messulam, Alec Moses
- 优先权： US25054 20080131; US35168 20080310; US43599 20080409
- 国际公布： WO2009095925 20090806
- 主分类号： C07K14/47
- IPC分类号： C07K14/47
摘要：
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KIAA0746, CD20 or CD55 antigens, which are differentially expressed in cancer and in specific blood cells, and diagnostic and therapeutic usages. This invention further relates to the discovery of extracellular domains of KIAA0746 and its variants, CD20 and its variants, CD55 and its variants, which are suitable targets for immunotherapy, cancer therapy, treatment of inflammatory, allergic and autoimmune disorders, and drug development.
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