公开(公告)号：EP3952910A1

公开(公告)日：2022-02-16

申请号：EP20717633.0

申请日：2020-04-06

申请人： Bayer Aktiengesellschaft ,  Compugen Ltd.

发明人： RÖSE, Lars ,  GRITZAN, Uwe ,  LIANG, Spencer ,  POW, Andrew ,  HUNTER, John ,  LEVY, Ofer ,  VAKNIN, Ilan

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  A61P37/06

公开(公告)号：EP3043819A1

公开(公告)日：2016-07-20

申请号：EP14844096.9

申请日：2014-09-11

申请人： Compugen Ltd.

发明人： LEVINE, Zurit ,  ROTMAN, Galit ,  DASSA, Liat ,  LEVY, Ofer ,  COJOCARU, Gad S. ,  TOPORIK, Amir ,  KLIGER, Yossef ,  POW, Andrew ,  LIANG, Spencer

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/574 ,  C07K16/30 ,  G01N33/564 ,  G01N33/569

CPC分类号： C07K16/28 ,  A61K31/664 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/5154 ,  C07K14/705 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30 ,  G01N33/564 ,  G01N33/57492 ,  G01N2800/24 ,  G01N2800/26 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/416 ,  Y02A50/421 ,  Y02A50/466 ,  Y02A50/491 ,  Y02A50/492 ,  Y02A50/55 ,  Y02A50/58 ,  A61K31/675 ,  A61K2039/5152 ,  A61K38/1774

摘要： The present invention relates to VSTM5-specific antibodies, antibody fragments, and VSTM5 polypeptides, conjugates and compositions comprising same, for modulating (antagonizing or agonizing) one or more of the effects of VSTM5 expression on immunity. More specifically, the present invention relates to VSTM5-specific antibodies, antibody fragments, and VSTM5 polypeptides, conjugates and compositions comprising same for treating and aiding in the diagnosis of cancer, infectious diseases and immune related diseases, e.g., those associated with aberrant (higher or lower than normal) VSTM5 expression by diseased and/or immune cells and/or aberrant (increased or reduced) VSTM5-mediated effects on immunity.

公开(公告)号：EP2744830A1

公开(公告)日：2014-06-25

申请号：EP13806165.0

申请日：2013-06-19

申请人： Compugen Ltd.

发明人： COJOCARU, Gady S. ,  DASSA, Liat ,  ROTMAN, Galit ,  LEVY, Ofer ,  POW, Andrew ,  SAMEACH-GREENWALD, Shirley ,  LEVINE, Zurit

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K31/675 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/507 ,  C07K14/70503 ,  C07K16/28 ,  C07K16/2818 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/734 ,  C07K2319/30 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/57492 ,  G01N2800/24 ,  G01N2800/26 ,  Y02A50/412 ,  Y02A50/423 ,  A61K2300/00

摘要： This invention relates to antibodies and antigen binding fragments and conjugates containing same, and/or alternative scaffolds, specific for LSR molecules, which are suitable drugs for immunotherapy and treatment of specific cancer.

公开(公告)号：EP3978929A1

公开(公告)日：2022-04-06

申请号：EP21188559.5

申请日：2016-02-19

申请人： Compugen Ltd.

发明人： WHITE, Mark ,  KUMAR, Sandeep ,  CHAN, Christopher ,  LIANG, Spencer ,  STAPELTON, Lance ,  DRAKE, Andrew W. ,  GOZLAN, Yosi ,  VAKNIN, Ilan ,  SAMEAH-GREENWALD, Shirley ,  DASSA, Liat ,  TIRAN, Zohar ,  COJOCARU, Gad S. ,  LEVY, Ofer ,  MACHLENKIN, Arthur ,  TOPORIK, Amir ,  KLIGER, Yossef ,  NEMZER, Sergey ,  NOVIK, Amit ,  BENITA, Yair

IPC分类号： G01N33/574 ,  A61P35/00 ,  A61P37/00 ,  C07K16/00 ,  C07K14/00 ,  G01N33/50

摘要： The present invention is directed to PVRIG polypeptides and their uses.

公开(公告)号：EP3717007A1

公开(公告)日：2020-10-07

申请号：EP18811506.7

申请日：2018-11-28

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft ,  Compugen Ltd.

发明人： RÖSE, Lars ,  GRITZAN, Uwe ,  HÜTTER, Julia ,  LIANG, Spencer ,  POW, Andrew ,  HUNTER, John ,  LEVY, Ofer ,  VAKNIN, Ilan

IPC分类号： A61K39/395 ,  A61K31/337 ,  C07K16/28 ,  A61P37/04 ,  A61P35/00

公开(公告)号：EP3259597A2

公开(公告)日：2017-12-27

申请号：EP16711051.9

申请日：2016-02-19

申请人： Compugen Ltd.

发明人： WHITE, Mark ,  KUMAR, Sandeep ,  CHAN, Christopher ,  LIANG, Spencer ,  STAPLETON, Lance ,  DRAKE, Andrew W. ,  GOZLAN, Yosi ,  VAKNIN, Iian ,  SAMEAH-GREENWALD, Shirley ,  DASSA, Liat ,  TIRAN, Zohar ,  COJOCARU, Gad, S. ,  LEVY, Ofer ,  MACHLENKIN, Arthur ,  TOPORIK, Amir ,  KLIGER, Yossef ,  NEMZER, Sergey ,  NOVIK, Amit ,  BENITA, Yair

IPC分类号： G01N33/574 ,  A61P35/00 ,  A61P37/00 ,  C07K16/00 ,  C07K14/00 ,  G01N33/50

CPC分类号： C07K16/1009 ,  A61K2039/507 ,  C07K7/06 ,  C07K14/70503 ,  C07K16/2803 ,  C07K16/2818 ,  C07K2317/74 ,  C07K2319/30 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/505 ,  G01N33/574 ,  G01N2333/70596 ,  G01N2500/02 ,  G01N2500/10 ,  Y02A50/466

摘要： The present invention is directed to PVRIG polypeptides and their uses.

公开(公告)号：EP2240196A2

公开(公告)日：2010-10-20

申请号：EP09703833.5

申请日：2009-01-22

申请人： Compugen Ltd.

发明人： KLIGER, Yossef ,  LEVY, Ofer ,  BORUKHOV, Itamar ,  WOOL, Assaf ,  SCHREIBER, Ehud ,  AMIR, Anat ,  LEVINE, Zurit ,  TIRAN, Zohar ,  OREN, Anat ,  TOPORIK, Amir

IPC分类号： A61K38/17 ,  C07K14/775 ,  C07K16/18

CPC分类号： C07K14/775 ,  A61K38/00

摘要： The subject invention provides clusterin-derived peptides or homologs or derivatives thereof, pharmaceutical composition comprising them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins comprising them.

公开(公告)号：EP3971211A1

公开(公告)日：2022-03-23

申请号：EP21188908.4

申请日：2016-07-13

申请人： Compugen Ltd.

发明人： DICKEN, Yosef ,  DASSA, Liat ,  NOVIK, Amit ,  TOPORIK, Amir ,  COJOCARU, Gad S. ,  KLIGER, Yossef ,  BENITA, Yair ,  LEVY, Ofer ,  VAKNIN, Ilan ,  MACHLENKIN, Arthur ,  HECHT, Iris ,  KIM, Jungmin ,  POW, Andrew ,  DRAKE, Andrew W.

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00

摘要： According to at least some embodiments of the present invention is directed to anti-HIDE1 antibodies and polypeptides and methods of using same.

公开(公告)号：EP3322733A1

公开(公告)日：2018-05-23

申请号：EP16751633.5

申请日：2016-07-13

申请人： Compugen Ltd.

发明人： DICKEN, Yosef ,  DASSA, Liat ,  NOVIK, Amit ,  TOPORIK, Amir ,  COJOCARU, Gad, S. ,  KLIGER, Yossef ,  BENITA, Yair ,  LEVY, Ofer ,  VAKNIN, Ilan ,  MACHLENKIN, Arthur ,  HECHT, Iris ,  KIM, Jungmin ,  POW, Andrew ,  DRAKE, Andrew, W.

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2803 ,  A61K31/513 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/572 ,  A61P35/00 ,  C07K14/70503 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30

摘要： According to at least some embodiments of the present invention is directed to anti-HIDE1 antibodies and polypeptides and methods of using same.

公开(公告)号：EP2675919A1

公开(公告)日：2013-12-25

申请号：EP12746695.1

申请日：2012-02-12

申请人： Compugen Ltd.

发明人： PINCHAS, Akiva ,  EDELHEIT-FLOHR, Sarit ,  BAZAK, Lily ,  LEVINE, Zurit ,  TOPORIK, Amir ,  LEVY, Ofer ,  ZEKHARYA, Tomer ,  WOOL, Assaf

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

摘要： The present invention discloses markers useful in predicting the responsiveness of a subject having, or at risk of developing rheumatoid arthritis (RA) to treatment with anti-TNF agents. Particularly, the present invention discloses the allelic configuration of the CD6 gene and/or the STXBP6 gene which is indicative of the degree of responsiveness to anti-TNFalpha treatment of RA.