发明公开
EP2249857A2 MALARIA VACCINE COMPOSITIONS AND CONSTITUENTS WHICH ELICIT CELL MEDIATED IMMUNITY
审中-公开
疟疾疫苗组合物和成分，细胞介导的免疫RELEASE
- 专利标题： MALARIA VACCINE COMPOSITIONS AND CONSTITUENTS WHICH ELICIT CELL MEDIATED IMMUNITY
- 专利标题（中）： 疟疾疫苗组合物和成分，细胞介导的免疫RELEASE
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申请号： EP09701498.9申请日： 2009-01-12
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公开(公告)号： EP2249857A2公开(公告)日： 2010-11-17
- 发明人: SHAFFERMAN, Avigdor , ZVI, Anat , FULKERSON, John , SADOFF, Jerald, C.
- 申请人： Aeras Global TB Vaccine Foundation
- 申请人地址： 1405 Research Boulevard, Suite 300 Rockville, MD 20850 US
- 专利权人： Aeras Global TB Vaccine Foundation
- 当前专利权人： Aeras Global TB Vaccine Foundation
- 当前专利权人地址： 1405 Research Boulevard, Suite 300 Rockville, MD 20850 US
- 代理机构： Kröncke, Rolf
- 优先权： US21996 20080118
- 国际公布： WO2009091692 20090723
- 主分类号： A61K38/08
- IPC分类号： A61K38/08
摘要：
Malaria vaccines based on polyepitope constructs that elicit cell-mediated immunity against a broad spectrum of malaria parasites and which cover the majority of HLA alleles are provided. Epitopes in the polyepitope constructs are from regions of the
Plasmodium falciparum circumsporozoite protein (CSP) known to contain CD4 and CD8 T cell epitopes, and include both epitopes from highly variable and highly conserved regions of CSP.
Plasmodium falciparum circumsporozoite protein (CSP) known to contain CD4 and CD8 T cell epitopes, and include both epitopes from highly variable and highly conserved regions of CSP.
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