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1.发明公开ENHANCEMENT OF TRANSGENE EXPRESSION FROM VIRAL-BASED VACCINE VECORS BY EXPRESSION OF SUPPRESSORS OF THE TYPE I INTERFERON RESPONSE 审中-公开改进疫苗载体的转基因表达对BASIS按类别划分的抑制器病毒表达我干扰素反应
公开(公告)号：EP2190979A1
公开(公告)日：2010-06-02
申请号：EP08798942.2
申请日：2008-08-29
发明人： SADOFF, Jerald, C. , FULKERSON, John , FAKRUDDIN-JAMILUDDIN, Mohamad , STONE, Michele, R. , ANANTHA, Ravi
CPC分类号： A61K39/04 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/55516 , C12N15/86 , C12N2710/10343 , C12N2710/14043 , C12N2710/14143 , C12N2760/16134 , C12N2840/203 , Y02A50/386 , Y02A50/394 , Y02A50/412 , Y02A50/466
摘要： Viral-based vectors are genetically engineered to express inhibitors of the anti-viral immune system (e.g. inhibitors of the type I interferon response) in order to enhance transgene expression. The transgenes may encode antigens or other therapeutic agents.
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2.发明公开RECOMBINANT MYCOBACTERIUM ENCODING A HEPARIN-BINDING HEMAGGLUTININ (HBHA) FUSION PROTEIN AND USES THEREOF 审中-公开重组结核分枝编码肝素结合血细胞凝集素（HBHA）的融合蛋白及其用途
公开(公告)号：EP2838990A1
公开(公告)日：2015-02-25
申请号：EP12874533.8
申请日：2012-04-16
申请人： Aeras Global TB Vaccine Foundation , INSERM - Institut National de la Santé et de la Recherche Médicale
CPC分类号： C07K14/35 , A61K39/04 , A61K49/0006 , A61K2039/523 , A61K2039/53 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/90
摘要： Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.
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3.发明公开RECOMBINANT BCG TUBERCULOSIS VACCINE FOR ELICITING IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS 有权重组卡介苗对结核病诱导免疫反应对结核分枝杆菌的
公开(公告)号：EP2235163A1
公开(公告)日：2010-10-06
申请号：EP08853526.5
申请日：2008-11-26
发明人： SHAFFERMAN, Avigdor , ZVI, Anat , ARIEL, Naomi , FULKERSON, John , SUN, Ronggai , CHANG, Rosemary , SADOFF, Jerald, C.
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/53 , C07K14/35
摘要： A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
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4.发明公开BACTERIAL PACKAGING STRAINS USEFUL FOR GENERATION AND PRODUCTION OF RECOMBINANT DOUBLE-STRANDED RNA NUCLEOCAPSIDS AND USES THEREOF 审中-公开创建和生产重组双链RNA核衣壳有用的细菌包装费用及其用途
公开(公告)号：EP2170385A2
公开(公告)日：2010-04-07
申请号：EP08827487.3
申请日：2008-05-30
IPC分类号： A61K39/295 , C12N15/74
CPC分类号： C12N15/88 , A61K39/04 , A61K2039/523 , A61K2039/53 , A61K2039/543 , A61K2039/57 , C12N15/86 , C12N2770/24211 , C12N2770/36143 , C12N2840/203
摘要： Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo. The packaging strains and rdsRNs may also comprise nucleic acid sequences that stabilize a closed loop eukaryotic translation complex; nucleic acid sequences encoding one or more proteins that interfere with a host cell type I interferon (IFN) response; as well as recombinant alphavirus replicons encoding a protein complex specific for plus strand RNA- dependent synthesis of minus strand RNA.
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5.发明授权RECOMBINANT BCG TUBERCULOSIS VACCINE FOR ELICITING IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS 有权重组卡介苗对结核病诱导免疫反应对结核分枝杆菌的
公开(公告)号：EP2235163B1
公开(公告)日：2014-01-08
申请号：EP08853526.5
申请日：2008-11-26
发明人： SHAFFERMAN, Avigdor , ZVI, Anat , ARIEL, Naomi , FULKERSON, John , SUN, Ronggai , CHANG, Rosemary , SADOFF, Jerald, C.
IPC分类号： C12N7/00 , A61K39/00 , A61K39/04 , C07K14/195 , C12N15/52
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/53 , C07K14/35
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6.发明公开MALARIA VACCINE COMPOSITIONS AND CONSTITUENTS WHICH ELICIT CELL MEDIATED IMMUNITY 审中-公开疟疾疫苗组合物和成分，细胞介导的免疫RELEASE
公开(公告)号：EP2249857A2
公开(公告)日：2010-11-17
申请号：EP09701498.9
申请日：2009-01-12
IPC分类号： A61K38/08
CPC分类号： C07K14/445 , C07K7/08
摘要： Malaria vaccines based on polyepitope constructs that elicit cell-mediated immunity against a broad spectrum of malaria parasites and which cover the majority of HLA alleles are provided. Epitopes in the polyepitope constructs are from regions of the
Plasmodium falciparum circumsporozoite protein (CSP) known to contain CD4 and CD8 T cell epitopes, and include both epitopes from highly variable and highly conserved regions of CSP.
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