发明公开
- 专利标题： Method of producing hydroxyalkyl starch derivatives
- 专利标题（中）： 一种制备羟烷基淀粉衍生物的方法
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申请号： EP10011836.3申请日： 2003-09-11
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公开(公告)号： EP2272865A3公开(公告)日： 2014-06-18
- 发明人: Zander, Norbert , Eichner, Wolfram , Conradt, Harald S.
- 申请人： Fresenius Kabi Deutschland GmbH
- 申请人地址： Else-Kröner-Strasse 1 61352 Bad Homburg DE
- 专利权人： Fresenius Kabi Deutschland GmbH
- 当前专利权人： Fresenius Kabi Deutschland GmbH
- 当前专利权人地址： Else-Kröner-Strasse 1 61352 Bad Homburg DE
- 代理机构： Altmann, Andreas
- 优先权： EP02020425 20020911; US409781P 20020911; PCT/EP03/08829 20030808
- 主分类号： C07K14/505
- IPC分类号： C07K14/505 ; C07K17/10 ; C08B31/00 ; C07K17/06 ; C12N15/12 ; A61K38/18 ; C07K14/55 ; C07K14/54 ; C07K14/56 ; C07K14/565 ; C07K14/53
摘要：
The present invention relates to a method of producing a hydroxyalkyl starch derivative, said hydroxyalkyl starch having a structure according to formula (I)
comprising reacting
- hydroxyalkyl starch of formula (I) at its optionally oxidized reducing end or
- a hydroxyalkyl starch derivative, obtainable by reacting hydroxyalkyl starch of formula (I) at its optionally oxidized reducing end with a compound (D), said compound (D) comprising
-- at least one functional group Z 1 capable of being reacted with the optionally oxidized reducing end of the hydroxyalkyl starch, and
-- at least one functional group W,
with a compound (L) comprising
- at least one functional group Z 1 capable of being reacted with said hydroxyalkyl starch, or at least one functional group Z 2 capable of being reacted with functional group W comprised in said hydroxyalkyl starch derivative, and
- at least one functional group X capable of being reacted with a functional group Y of a further compound (M),
wherein said functional group Y is selected from the group consisting of an aldehyd group, a keto group, a hemiacetal group, an acetal group, and a thio group. The present invention further relates to the hydroxyalkyl starch derivatives as such ans a pharmaceutical composition comprising the hydroxyalkyl starch derivatives.
comprising reacting
- hydroxyalkyl starch of formula (I) at its optionally oxidized reducing end or
- a hydroxyalkyl starch derivative, obtainable by reacting hydroxyalkyl starch of formula (I) at its optionally oxidized reducing end with a compound (D), said compound (D) comprising
-- at least one functional group Z 1 capable of being reacted with the optionally oxidized reducing end of the hydroxyalkyl starch, and
-- at least one functional group W,
with a compound (L) comprising
- at least one functional group Z 1 capable of being reacted with said hydroxyalkyl starch, or at least one functional group Z 2 capable of being reacted with functional group W comprised in said hydroxyalkyl starch derivative, and
- at least one functional group X capable of being reacted with a functional group Y of a further compound (M),
wherein said functional group Y is selected from the group consisting of an aldehyd group, a keto group, a hemiacetal group, an acetal group, and a thio group. The present invention further relates to the hydroxyalkyl starch derivatives as such ans a pharmaceutical composition comprising the hydroxyalkyl starch derivatives.
公开/授权文献
- EP2272865A2 Method of producing hydroxyalkyl starch derivatives 公开/授权日：2011-01-12
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