发明公开
- 专利标题： HSA-free formulations of interferon-beta
- 专利标题（中）： HSA-frei干扰素-βFormulierungen
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申请号： EP10180630.5申请日： 2001-10-26
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公开(公告)号： EP2283896A2公开(公告)日： 2011-02-16
- 发明人: Shirley, Bret , Choe, Minna , Tellers, Melanie , Babuka, Susan
- 申请人： Novartis Vaccines and Diagnostics, Inc.
- 申请人地址： 4560 Horton Street Emeryville, CA 94608 US
- 专利权人： Novartis Vaccines and Diagnostics, Inc.
- 当前专利权人： Novartis Vaccines and Diagnostics, Inc.
- 当前专利权人地址： 4560 Horton Street Emeryville, CA 94608 US
- 代理机构： Marshall, Cameron John
- 优先权： US282614P 20010409; US330404P 20011018; US35397 20011025
- 主分类号： A61P25/00
- IPC分类号： A61P25/00 ; A61K38/21 ; A61K47/18
摘要：
Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (1FN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.
公开/授权文献
- EP2283896B1 HSA-free formulations of interferon-beta 公开/授权日：2014-09-03
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