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公开(公告)号：EP2123292B1
公开(公告)日：2016-05-04
申请号：EP09161208.5
申请日：1999-08-27
IPC分类号： A61K38/18
CPC分类号： A61K38/1825
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公开(公告)号：EP2295402B1
公开(公告)日：2015-08-12
申请号：EP10179798.3
申请日：2004-01-08
发明人： Andersen, Niels H. , Bowman, Jason , Erwin, Alice , Harwood, Eric , Kline, Toni , Mdluli, Khisimuzi , Ng, Simon , Pfister, Keith B. , Shawar, Ribhi , Wagman, Allan , Yabannavar, Asha
IPC分类号： C07C233/00 , A61K31/16 , A61K31/165 , A61K45/06 , A61P31/04 , C07D333/58 , C07C255/44 , C07D213/74 , C07C255/57 , C07C259/06 , C07D213/80 , C07D213/81 , C07D213/82
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
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公开(公告)号：EP1807116B1
公开(公告)日：2015-05-06
申请号：EP05823432.9
申请日：2005-11-03
IPC分类号： A61K48/00 , A61K39/155
CPC分类号： C07K14/005 , A61K9/0021 , A61K39/12 , A61K39/145 , A61K2039/54 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N7/00 , C12N2760/16034 , C12N2760/16134 , C12N2760/16234
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公开(公告)号：EP1834671A3
公开(公告)日：2013-05-22
申请号：EP06076491.7
申请日：1993-07-08
发明人： De Boer, Mark , Conroy, Leah B.
IPC分类号： A61P37/00 , A61K39/395 , C07K16/28 , C12N5/12
CPC分类号： C07K16/2827 , A61K2039/505 , C07K16/2878 , C07K2317/24 , C07K2317/73 , C07K2319/30
摘要： The present invention relates to a method of generating antibodies directed against cell surface antigens and it uses recombinant insect cells as immunogens. The insect cells have been transfected with coding regions for a molecule containing a cell surface antigen and these antigens are expressed on the surface of the insect cells. Host animals are immunized with these transfected insect cells to generate antibodies directed against the cell surface antigen. Antibody-producing cells from the host animal are used to generate monoclonal antibody-producing hybridoma cells. Sera and hybridoma supernatants can be tested for the presence of antibodies against the surface antigen, using the transfected cells in a screening assay. Specific antibodies that have been generated by the present method are anti-B7 and anti-CD40 antibodies and they can be used to prevent or treat an antibody-mediated or immune system disease in a patient. The anti-B7 antibodies can be used to cause T cell anergy, treat allograft transplant rejection, treat graft versus host disease, and prevent or treat rheumatoid arthritis. An immunosuppressive agent may be co-administered with the antibody. The anti-CD40 antibodies which bind to the CD40 antigen can be used to prevent the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
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公开(公告)号：EP0574402B2
公开(公告)日：2012-08-01
申请号：EP92901535.2
申请日：1991-11-26
发明人： BARR, Philip, J. , BRAKE, Anthony, J. , KAUFMAN, Randal, J. 111 Marlborough Street , TEKAMP-OLSON, Patricia , WASLEY, Louise , WONG, Polly, A.
CPC分类号： C12N9/6454 , C07K14/755
摘要： Compositions and methods are provided for endopeptidase production and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides, including proteins requiring gamma-carboxylation for biological activity. These compositions and methods utilize recombinant PACE, a mammalian endopeptidase that is specific for dibasic amino acid sites.
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6.发明授权
公开(公告)号：EP1985701B1
公开(公告)日：2012-05-30
申请号：EP08010460.7
申请日：2001-01-09
IPC分类号： C12N15/11 , C12N15/12 , C12N15/62 , C12N15/86 , C12N5/10 , C07K14/47 , C07K16/18 , A61K31/713 , C12Q1/68 , G01N33/577 , G06F17/30
CPC分类号： C07K14/47 , C07K16/18 , C07K2319/00
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公开(公告)号：EP1381432B9
公开(公告)日：2012-04-25
申请号：EP01988466.7
申请日：2001-10-26
发明人： SHIRLEY, Bret, A., Chiron Corporation , CHOE, Minna, Chiron Corporation , TELLERS, Melanie, Chiron Corporation , BABUKA, Susan, Chiron Corporation , CHEN, Bao-Lu, Novartis Vaccines and Diagnostics, Inc. , HORA, Maninder, Novartis Vaccines and Diagnostics, Inc.
CPC分类号： A61K9/0019 , A61K38/1816 , A61K38/215 , A61K47/12 , A61K47/183
摘要： Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilized in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.
摘要翻译： 提供了包含基本上单体干扰素-β（IFN-β）的稳定的药物组合物以及可用于其制备的方法。 该组合物包含溶解在低离子强度制剂中的IFN-β，其将组合物维持在约5.0的pH。 提供了制备这些组合物的方法，以及提高IFN-β在药物组合物中的溶解度。
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公开(公告)号：EP1675869B1
公开(公告)日：2012-02-15
申请号：EP04796096.8
申请日：2004-10-22
IPC分类号： A61K47/18 , A61K9/00 , C07K14/195 , A61K39/39 , A61K38/45
CPC分类号： A61K39/39 , A61K9/0019 , A61K38/45 , A61K39/00 , A61K47/183 , A61K47/186 , A61K2039/55544 , C07K14/195 , Y02A50/472
摘要： This invention relates to the stabilization of a bacterial ADP-ribosylating exotoxin class protein (bARE), a method for analysing a bARE class protein, a method for the stabilization of the bARE class bacterial protein, compositions comprising a stabilized bARE protein, compositions comprising a substantially integral bARE class protein and immunogenic composition formulations incorporating same.
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公开(公告)号：EP1532161B1
公开(公告)日：2012-02-15
申请号：EP03741966.0
申请日：2003-06-13
发明人： HARDY, Stephen, F. C/O Chiron Corporation , DONNELLY, John, J., III C/O Chiron Corporation , ZUR MEGEDE, Jan, T. C/O Chiron Corporation
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/005 , C12N2740/10022 , C12N2740/10034
摘要： A nucleic acid vector comprising: (i) a promoter; (ii) a sequence encoding a HML-2 polypeptide operably linked to said promoter; and (iii) a selectable marker. Preferred vectors comprise: (I) a eukaryotic promoter; (ii) a sequence encoding a HML-2 polypeptide downstream of and operably linked to said promoter; (iii) a prokaryotic selectable marker; (iv) a prokaryotic origin of replication; and (v) a eukaryotic transcription terminator downstream of and operably linked to said sequence encoding a HML-2 polypeptide. Vectors of the invention are particularly useful for expression of HML-2 polypeptides either in vitro (e.g. for later purification). Or in vivo (e.g. for nucleic acid immunization). They are well suited to nucleic acid immunization against prostrate tumors. A preferred HML-2 is PCAV, which is located in chromosome 22 at 20.428 megabases (22q11.2).
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公开(公告)号：EP1717251B1
公开(公告)日：2012-01-18
申请号：EP06005656.1
申请日：2001-10-02
发明人： Chu, Keting , Masuoka, Lorianne
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , A61P37/00
CPC分类号： C07K16/2878 , A01K2217/05 , A61K2039/505 , C07K2317/21 , C12N2799/026
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