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公开(公告)号：EP2283897B1
公开(公告)日：2014-02-26
申请号：EP10180658.6
申请日：2001-10-26
发明人： Shirley, Bret , Choe, Minna , Tellers, Melanie , Babuka, Susan
CPC分类号： A61K9/0019 , A61K38/1816 , A61K38/215 , A61K47/12 , A61K47/183
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公开(公告)号：EP2283897A3
公开(公告)日：2011-06-15
申请号：EP10180658.6
申请日：2001-10-26
发明人： Shirley, Bret , Choe, Minna , Tellers, Melanie , Babuka, Susan
CPC分类号： A61K9/0019 , A61K38/1816 , A61K38/215 , A61K47/12 , A61K47/183
摘要： Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.
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公开(公告)号：EP2283897A2
公开(公告)日：2011-02-16
申请号：EP10180658.6
申请日：2001-10-26
发明人： Shirley, Bret , Choe, Minna , Tellers, Melanie , Babuka, Susan
CPC分类号： A61K9/0019 , A61K38/1816 , A61K38/215 , A61K47/12 , A61K47/183
摘要： Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.
摘要翻译： 提供包含基本上单体的干扰素-β（IFN-2）的稳定的药物组合物和其制备中有用的方法。 组合物包含溶解在低离子强度制剂中的IFN-2，其将组合物保持在约5.0的pH。 提供了制备这些组合物并提高IFN-²在药物组合物中的溶解度的方法。
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公开(公告)号：EP2283896A2
公开(公告)日：2011-02-16
申请号：EP10180630.5
申请日：2001-10-26
发明人： Shirley, Bret , Choe, Minna , Tellers, Melanie , Babuka, Susan
CPC分类号： A61K9/0019 , A61K38/1816 , A61K38/215 , A61K47/12 , A61K47/183
摘要： Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (1FN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.
摘要翻译： 提供包含基本上单体的干扰素-β（1FN-2）的稳定的药物组合物和其制备中有用的方法。 组合物包含溶解在低离子强度制剂中的IFN-2，其将组合物保持在约5.0的pH。 提供了制备这些组合物并提高IFN-²在药物组合物中的溶解度的方法。
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公开(公告)号：EP2283896B1
公开(公告)日：2014-09-03
申请号：EP10180630.5
申请日：2001-10-26
发明人： Shirley, Bret , Choe, Minna , Tellers, Melanie , Babuka, Susan
CPC分类号： A61K9/0019 , A61K38/1816 , A61K38/215 , A61K47/12 , A61K47/183
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公开(公告)号：EP2283896A3
公开(公告)日：2011-05-25
申请号：EP10180630.5
申请日：2001-10-26
发明人： Shirley, Bret , Choe, Minna , Tellers, Melanie , Babuka, Susan
CPC分类号： A61K9/0019 , A61K38/1816 , A61K38/215 , A61K47/12 , A61K47/183
摘要： Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (1FN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.
摘要翻译： 提供了包含基本上单体干扰素-β（1FN-β）的稳定的药物组合物和可用于其制备的方法。 该组合物包含在低离子强度制剂中溶解的IFN-β，其将组合物维持在约5.0的pH。 提供了制备这些组合物的方法以及提高IFN-β在药物组合物中的溶解度的方法。
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