发明公开
EP2286792A1 Microemulsions with an adsorbent surface, comprising a microdroplet emulsion
审中-公开
Mikroemulsionen mit einer adsorptionbierendenOberfläche，enthaltend eine Mikrotropfenemulsion
- 专利标题： Microemulsions with an adsorbent surface, comprising a microdroplet emulsion
- 专利标题（中）： Mikroemulsionen mit einer adsorptionbierendenOberfläche，enthaltend eine Mikrotropfenemulsion
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申请号： EP10179804.9申请日： 2000-02-09
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公开(公告)号： EP2286792A1公开(公告)日： 2011-02-23
- 发明人: O'Hagan, Derek , Ott, Gary S. , Donnelly, John , Kazzaz, Jina , Ugozzoli, Mildred , Singh, Manmohan , Barackman, John
- 申请人： Novartis Vaccines and Diagnostics, Inc.
- 申请人地址： 4560 Horton Street Emeryville, CA 94608 US
- 专利权人： Novartis Vaccines and Diagnostics, Inc.
- 当前专利权人： Novartis Vaccines and Diagnostics, Inc.
- 当前专利权人地址： 4560 Horton Street Emeryville, CA 94608 US
- 代理机构： Marshall, Cameron John
- 优先权： US121858P 19990226; US146391P 19990729; US161997P 19991028
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/107
摘要：
Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a microdroplet emulsion comprising a metabolisable oil, an emulsifying agent, wherein said emulsifying agent comprises a detergent and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.
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